Collect. Czech. Chem. Commun. 1999, 64, 363-376
https://doi.org/10.1135/cccc19990363

Molecular Modification of Anpirtoline, a Non-Opioid Centrally Acting Analgesic

Stanislav Rádl*, Wieland Hafner, Petr Hezký, Ivan Krejčí, Jan Proška and Jan Taimr

Research Institute of Pharmacy and Biochemistry, 130 60 Prague 3, Czech Republic

Individual author index pages


Other CCCC articles of these authors

  • Stanislav Rádl*, Jan Stach, Josef Černý and Ondřej Klecán
    An efficient synthesis of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine, a key intermediate in the licofelone synthesis
    2009, Vol. 74, Issue 6, pp. 1011–1022 [Abstract]
  • Jaroslav Havlíček*, Zuzana Mandelová, Ruediger Weisemann, Ivo Střelec, Lukáš Plaček and Stanislav Rádl
    Identification, synthesis and structural determination of some impurities of candesartan cilexetil
    2009, Vol. 74, Issue 2, pp. 347–362 [Abstract]
  • Jan Stach*, Jaroslav Havlíček, Lukáš Plaček and Stanislav Rádl
    Synthesis of Some Impurities and/or Degradation Products of Atorvastatin
    2008, Vol. 73, Issue 2, pp. 229–246 [Abstract]
  • Stanislav Rádl*, Ondřej Klecán, Robert Klvaňa and Jaroslav Havlíček
    A New Synthesis of Rizatriptan Based on Radical Cyclization
    2008, Vol. 73, Issue 1, pp. 116–126 [Abstract]
  • Stanislav Rádl* and Iva Obadalová
    Utilization of Aromatic Denitrocyclization Reaction for the Synthesis of 3-Unsubstituted 1,4-Dihydroquinolin-4-one Derivatives
    2004, Vol. 69, Issue 4, pp. 822–832 [Abstract]
  • Stanislav Rádl*, Petr Hezký, Petr Konvička and Ivan Krejčí
    Synthesis and Analgesic Activity of Some Substituted 1-Benzofurans and 1-Benzothiophenes
    2000, Vol. 65, Issue 7, pp. 1093–1108 [Abstract]
  • Stanislav Rádl*, Petr Hezký, Jitka Urbánková, Petr Váchal and Ivan Krejčí
    Synthesis and Analgesic Activity of Some 1-Benzofurans, 1-Benzothiophenes and Indoles
    2000, Vol. 65, Issue 2, pp. 280–296 [Abstract]
  • Marek Urbanský*, Jan Proška, Jan Říčný and Pavel Drašar
    Truxillic Acid Derivatives, Neuromuscular Blocking Agents with Very High Affinity for the Allosteric Binding Site of Muscarinic Acetylcholine Receptors
    1999, Vol. 64, Issue 12, pp. 1980–1992 [Abstract]
  • Marek Urbanský*, Jan Proška and Pavel Drašar
    Fused Thiazoloandrostanes and Their Quaternary Salts, Synthesis and Cooperative Ligand Binding to Muscarinic Acetylcholine Receptor
    1999, Vol. 64, Issue 9, pp. 1457–1470 [Abstract]
  • Stanislav Rádl*, Wieland Hafner, Petr Hezký, Ivan Krejčí, Jan Proška and Josef Hájíček
    Synthesis and Antinociceptive Activity of Some 3-Chlorophenyl- and 6-Chloropyridin-2-yl Derivatives
    1999, Vol. 64, Issue 2, pp. 377–388 [Abstract]
  • Evžen Kasafírek, Jaroslav Moural, Jarmila Vinšová, Antonín Šturc and Jan Taimr
    Cyclic Dipeptides with 1-Aminocyclopropane-1-carboxylic Acid
    1997, Vol. 62, Issue 6, pp. 941–947 [Abstract]
  • Stanislav Rádl
    Synthetic Studies Connected with the Preparation of 4-Cyclopropyl-7-fluoro-6-(4-methylpiperazin-1-yl)-1,2,4,9-tetrahydrothiazolo[5,4-b]quinoline-2,9-dione
    1997, Vol. 62, Issue 5, pp. 791–799 [Abstract]
  • Miroslav Kuchař, Marie Poppová, Antonín Jandera, Vladimíra Panajotovová, Hana Zůnová, Miloš Buděšínský, Hana Tomková, Alexandr Jegorov and Jan Taimr
    Chiral Forms of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid (Flobufen) and Its Metabolite.Synthesis and Basic Biological Properties
    1997, Vol. 62, Issue 3, pp. 498–509 [Abstract]
  • Alexandra Šilhánková, Karel Šindelář, Karel Dobrovský, Ivan Krejčí, Jarmila Hodková and Zdeněk Polívka
    Synthesis of New L-Proline Amides with Anticonvulsive Effect
    1996, Vol. 61, Issue 7, pp. 1085–1092 [Abstract]
  • Vladimír Valenta, Karel Dobrovský, Ivan Krejčí and Zdeněk Polívka
    Potential Antagonists of Excitatory Amino Acids and Anticonvulsants: Some Heterocyclic (±)-Pyrrolidine-2-carboxamides
    1996, Vol. 61, Issue 7, pp. 1077–1084 [Abstract]
  • Stanislav Rádl
    Preparation of 1-Hydroxyxanthen-9(9H)-ones and 1-Hydroxyacridin-9(10H)-ones via Corresponding 3,4-Dihydro-1,9(2H)-diones
    1995, Vol. 60, Issue 12, pp. 2127–2136 [Abstract]
  • Miroslav Kuchař, Václav Vosátka, Marie Poppová, Eva Knězová, Vladimíra Panajotovová, Hana Tomková and Jan Taimr
    Some Analogs of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid: Synthesis and Antiinflammatory Activity
    1995, Vol. 60, Issue 6, pp. 1026–1033 [Abstract]
  • Karel Šindelář, Karel Dobrovský, Ivan Krejčí and Zdeněk Polívka
    Substituted 1-(2-Thienyl)cyclohexylamines and Related Compounds as Potential NMDA Antagonists
    1995, Vol. 60, Issue 5, pp. 894–902 [Abstract]
  • Stanislav Rádl
    Synthesis of 3-Amino- and 3-Acylamino-1-cyclopropylquinolin-4(1H)-ones
    1994, Vol. 59, Issue 9, pp. 2123–2126 [Abstract]
  • Stanislav Rádl
    Synthesis of Ethyl 1-Ethyl-6-fluoro-1,4-dihydro-8-hydroxy-4-oxoquinoline-3-carboxylate
    1994, Vol. 59, Issue 9, pp. 2119–2122 [Abstract]
  • Vladimír Valenta, Jiří Urban, Jan Taimr and Zdeněk Polívka
    Potential Nootropic Agents: Synthesis of Some 1,4-Disubstituted 2-Oxopyrrolidines and Some Related Compounds
    1994, Vol. 59, Issue 5, pp. 1126–1136 [Abstract]
  • Alexandra Šilhánková, Karel Dobrovský, Ivan Krejčí and Zdeněk Polívka
    Compounds Interacting with the Neuroexcitatory Amino Acids: Synthesis of 2-(4-Aralkylpiperazine-1-yl)-1-arylethanols
    1994, Vol. 59, Issue 3, pp. 658–666 [Abstract]
  • Stanislav Rádl
    Preparation of Some Pyrazole Derivatives by Extrusion of Elemental Sulfur from 1,3,4-Thiadiazines
    1992, Vol. 57, Issue 3, pp. 656–659 [Abstract]
  • Stanislav Rádl, Jaroslav Moural and Radoslava Bendová
    Preparation of Some 2,3-Dihydro-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine Derivatives
    1992, Vol. 57, Issue 1, pp. 216–218 [Abstract]
  • Stanislav Rádl and Lenka Kovářová
    Preparation of Some Substituted 9,10-Dihydro-1-hydroxy-9-oxoacridine Derivatives
    1992, Vol. 57, Issue 1, pp. 212–215 [Abstract]
  • Stanislav Rádl and Magda Janichová
    Synthesis and Antibacterial Activity of Some 3-Hydroxyquinolones
    1992, Vol. 57, Issue 1, pp. 188–193 [Abstract]
  • Stanislav Rádl and Pavel Hradil
    Synthesis of some 1-alkyl-1,4-dihydro-4-oxo-1,7-naphthyridine-3-carboxylic acids
    1991, Vol. 56, Issue 11, pp. 2420–2429 [Abstract]
  • Stanislav Rádl and Lenka Kovářová
    Some reactions of N-propadienyl-4-quinolones
    1991, Vol. 56, Issue 11, pp. 2413–2419 [Abstract]
  • Stanislav Rádl and Lenka Kovářová
    Synthesis and antibacterial activity of new 7-substituted fluoroquinolones
    1991, Vol. 56, Issue 11, pp. 2406–2412 [Abstract]
  • Stanislav Rádl, Lenka Kovářová, Jaroslav Moural and Radoslava Bendová
    Structural modification and new methods for preparation of ofloxacin analogs
    1991, Vol. 56, Issue 9, pp. 1937–1943 [Abstract]
  • Stanislav Rádl, Lenka Kovářová and Jiří Holoubek
    Synthesis and antibacterial activity of some 1-(2-propynyl) and 1-propadienyl derivatives of 1,4-dihydro-4-oxoquinoline-3-carboxylic acids and similar heterocycles
    1991, Vol. 56, Issue 2, pp. 439–448 [Abstract]
  • Vladimír Valenta, Jiří Holubek, Emil Svátek, Martin Valchář, Ivan Krejčí and Miroslav Protiva
    Potential nootropic agents: Synthesis of some (2-oxo-1-pyrrolidinyl)acetamides and some related compounds
    1990, Vol. 55, Issue 11, pp. 2756–2764 [Abstract]
  • Vladimír Valenta, Karel Šindelář, Jiří Holubek, Miroslav Ryska, Ivan Krejčí, Antonín Dlabač and Miroslav Protiva
    Potential nootropic agents: Synthesis of a series of (2-oxo-1-pyrrolidinyl)acetic acid piperazides
    1990, Vol. 55, Issue 6, pp. 1613–1629 [Abstract]
  • Stanislav Rádl, Jaroslav Moural and Radoslava Bendová
    Synthesis and antibacterial activity of some 1-aryl-1,4-dihydro-4-oxocinnoline-3-carboxylic acids
    1990, Vol. 55, Issue 5, pp. 1311–1320 [Abstract]
  • Miroslav Protiva, Vladimír Valenta, Zdeňka Kopicová, Juraj Lukáč, Jiří Holubek and Ivan Krejčí
    Potential cerebral stimulants: Esters of 2-dimethylaminoethanol with some lipophilic carboxylic acids
    1990, Vol. 55, Issue 5, pp. 1278–1289 [Abstract]
  • Miloš Beran, Antonín Černý, Miroslav Kuchař, Hana Adamírová, Jiří Holubek, Jan Taimr, Jaroslav Vachek, Maria Frühaufová, Karel Řežábek, Martin Valchář and Ivan Krejčí
    9,10-Dihydroergopeptines modified in position 6
    1990, Vol. 55, Issue 3, pp. 819–832 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Synthesis of some 1-aryl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids and their antibacterial activity
    1989, Vol. 54, Issue 8, pp. 2181–2189 [Abstract]
  • Hana Hulinská, Miroslav Ryska, Ivan Koruna, Jiří Holubek, Jan Taimr, Emil Svátek and Miroslav Protiva
    Some further 2-(4-substituted 1-piperazinyl)acetamides derived from 6,11-dihydrodibenzo[b,e]thiepin. Transformations of 6,11-dihydrodibenzo[b,e]thiepin derivatives into anthraquinones, anthrones and anthracenes
    1989, Vol. 54, Issue 5, pp. 1388–1402 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Synthesis and antimicrobial activity of some 3-oxo-3H-pyrido[3,2,1-kl]phenoxazine-2-carboxylic acids
    1989, Vol. 54, Issue 2, pp. 506–515 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Synthesis and biological activity of some basic-substituted 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinolines
    1988, Vol. 53, Issue 8, pp. 1812–1819 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity
    1987, Vol. 52, Issue 3, pp. 788–792 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Syntheses of some 4-dialkylaminoalkylamino derivatives of 2,3-dimethyl-2H- and 3,9-dimethyl-9H-pyrazolo[3,4-b]quinoline
    1986, Vol. 51, Issue 8, pp. 1692–1697 [Abstract]
  • Stanislav Rádl, Viktor Zikán and František Šmejkal
    Syntheses of some N-carboxymethyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H-(2H)-pyrazolo[3,4-b]quinoline with antiviral effects
    1985, Vol. 50, Issue 9, pp. 2010–2014 [Abstract]
  • Stanislav Rádl, Viktor Zikán and František Šmejkal
    Syntheses of 1, 2, and 9-methyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity
    1985, Vol. 50, Issue 5, pp. 1057–1063 [Abstract]
  • František Brtník, Ivan Krejčí, Běla Kupková, Pavel Hrbas, Jana Škopková, Tomislav Barth and Karel Jošt
    Vasopressin analogues with effect on central nervous system: Synthesis and biological properties
    1983, Vol. 48, Issue 10, pp. 2862–2873 [Abstract]
  • Evžen Kasafírek, Vladimír Felt, Ivan Krejčí and Jiří Michalský
    Synthesis of analogues of the thyreotropin releasing factor containing 2-oxoimidazolidine-1-carboxylic acid
    1980, Vol. 45, Issue 2, pp. 452–456 [Abstract]
  • Evžen Kasafírek, Ivan Krejčí and Vladimír Felt
    Synthesis of analogues of the melanocyte-stimulating hormone release-inhibiting factor containing 2-oxoimidazolidine-1-carboxylic acid
    1980, Vol. 45, Issue 1, pp. 294–297 [Abstract]
  • Miloslav Ferles, Oldřich Kocián and Stanislav Rádl
    Reduction of some pyridine derivatives with zinc and formic acid
    1978, Vol. 43, Issue 6, pp. 1628–1633 [Abstract]
  • Zdenko Procházka, Ivan Krejčí, Běla Kupková, Jiřina Slaninová, Vera Bojanovska, Zdeněk Prusík, Ilse A. Vosekalna, Petr Maloň, Tomislav Barth, Ivo Frič, Karel Bláha and Karel Jošt
    Synthesis and properties of the Nα-glycyl-glycyl-glycyl-8-lysine-vasopressin and its des-glycinamide derivative
    1978, Vol. 43, Issue 5, pp. 1285–1299 [Abstract]