Collect. Czech. Chem. Commun. 1980, 45, 452-456

Synthesis of analogues of the thyreotropin releasing factor containing 2-oxoimidazolidine-1-carboxylic acid

Evžen Kasafíreka, Vladimír Feltb, Ivan Krejčía and Jiří Michalskýa

a Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
b Research Institute for Endocrinology, 116 94 Prague 1


2-Oxoimidazolidine-1-carbonyl-histidyl-proline amide (I) and 2-oxoimidazolidine-1-carbonyl-histidyl-phenylalanine amide (II) were synthesized by conventional chemical methods. 4,4'-Dimethoxybenzhydryl and 3,3',4,4'-tetramethoxybenzhydryl groups were used for protection of primary amide functions. Both analogues, I and II, did not exhibit the increase in thyroxine (radioimmunoassay) when applied to male rats intraperitoneally.