Collect. Czech. Chem. Commun. 1994, 59, 2119-2122

Synthesis of Ethyl 1-Ethyl-6-fluoro-1,4-dihydro-8-hydroxy-4-oxoquinoline-3-carboxylate

Stanislav Rádl

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3, Czech Republic


In connection with our research into antibacterial fluoroquinolones we required ethyl 1-ethyl-6-fluoro-1,4-dihydro-8-hydroxy-4-oxoquinoline-3-carboxylate (IIc) as an intermediate. This paper describes synthesis of this compound and the corresponding carboxylic acid.