Collect. Czech. Chem. Commun. 1994, 59, 2123-2126

Synthesis of 3-Amino- and 3-Acylamino-1-cyclopropylquinolin-4(1H)-ones

Stanislav Rádl

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3, Czech Republic


Antibacterial quinolones have attracted an increasing attention as a source of clinically useful drugs. During our research into antibacterial quinolones we were also interested in compounds having at the position 3 various groups that could mimic the carboxylic group present in these drugs. Having our own procedure for the preparation of 3-nitroquinolones, we decided to investigate the question of possible activity of 3-amino derivatives and 3-acylamino derivatives.