Collect. Czech. Chem. Commun. 1994, 59, 658-666

Compounds Interacting with the Neuroexcitatory Amino Acids: Synthesis of 2-(4-Aralkylpiperazine-1-yl)-1-arylethanols

Alexandra Šilhánková, Karel Dobrovský, Ivan Krejčí and Zdeněk Polívka

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3, Czech Republic


Amino ketones Ia - If and III were synthesized. Their reduction gave corresponding alcohols IIa - IIf, IVa and IVb. These were evaluated by methods of biochemical and behavioural pharmacology.