Antihistamine Substances. Tricyclic Analogues of <i>N</i>-(4,4-Diphenyl-3-butene-1-yl)nipecotic Acid and Some Related Compounds

Šindelář, Karel; Šilhánková, Alexandra; Urban, Jiří; Metyš, Jan; Valchář, Martin; Polívka, Zdeněk

doi:10.1135/cccc19940667

CCCC > Archive > 1994, Volume 59 > Issue 3 > p. 667

Antihistamine Substances. Tricyclic Analogues of N-(4,4-Diphenyl-3-butene-1-yl)nipecotic Acid and Some Related Compounds

Karel Šindelář^a, Alexandra Šilhánková^a, Jiří Urban^b, Jan Metyš^a, Martin Valchář^a and Zdeněk Polívka^a

^a Research Institute for Pharmacy and Biochemistry, 130 00 Prague 3, Czech Republic
^b J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, 182 23 Prague 8, Czech Republic

Abstract

Alkylation of ethyl nipecotate with bromides VII - X gave amino esters Ib - Vb. Alkylation of ethyl piperazine-2-carboxylate with 4-bromo-1,1-diphenyl-1-butene afforded compound Vb. Final product Ia - Va were obtained by acid hydrolysis of corresponding esters Ib - Vb. Some of the compounds showed significant antihistamine and antiulcer activities.

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Antihistamine Substances. Tricyclic Analogues of N-(4,4-Diphenyl-3-butene-1-yl)nipecotic Acid and Some Related Compounds

Abstract