Collect. Czech. Chem. Commun. 1991, 56, 2406-2412

Synthesis and antibacterial activity of new 7-substituted fluoroquinolones

Stanislav Rádl and Lenka Kovářová

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Reaction of substituted 3-carboxyquinolone derivatives IIIa, IIIb, IIIc, and IV with 4-pyridone ethylene ketal in pyridine afforded corresponding 7-substituted derivatives VIa, VIb, VIc, and VIIa, respectively. Acidic deprotection of these compounds yielded respective oxo derivatives VId,VIe, VIf, and VIIb which were converted to their oximes If, Ig, Ih, and IIb.