Collect. Czech. Chem. Commun. 1991, 56, 2402-2405

Search for new analeptics: Homoanalogues of dimefline-type derivatives

Maria Carraraa, Francesca Capolongoa, Lorenzo Cimaa, Giuseppina Fabbrib, Angela Rampab, Piero Valentib and Paolo Da Reb

a Department of Pharmacology, University of Padua, Italy
b Department of Pharmaceutical Sciences, University of Bologna, Italy


The preparation and the pharmacological profile of a selected number of homologues at C2 (homoflavones) of dimefline-type analeptics are described. The structural modifications introduced in I seems to cause a remarkable alteration of the CNS stimulating pattern so that the new compounds are to be considered as minor analeptics.