Collect. Czech. Chem. Commun.
1991, 56, 2395-2401
https://doi.org/10.1135/cccc19912395
Relations between structure and antituberculotic activity in a group of 10-piperazino-10,11-dihydrodibenzo[b,f]thiepins
Karel Waisser and Jana Bořková
Department of Inorganic and Organic Chemistry, Pharmaceutical Faculty, Charles University, 501 65 Hradec Králové
Abstract
Relations between chemical structure and activity to Mycobacterium tuberculosis have been looked for within a group of the derivatives of 10-piperazino-10,11-dihydrodibenzo[b,f]thiepins prepared by Protiva et al. It has been found that the most reliable results are obtained with application of the model by Free and Wilson. The activity can be considered additive with regard to the contributions of the molecular segments varied.
