Collect. Czech. Chem. Commun. 1991, 56, 2389-2394

Antimycobacterial derivatives of tetrazole

Karel Waissera, Jiří Vanžuraa, Alexandr Hrabáleka, Jarmila Vinšováa, Štefan Grešáka, Jiří Hruškaa and Želimíra Odlerováb

a Department of Inorganic and Organic Chemistry, Pharmaceutical Faculty, Charles University, 501 65 Hradec Králové
b Research Institute of Preventive Medicine, 833 01 Bratislava


A synthesis of (1-phenyltetrazol-5-ylthio)acetic acid derivatives has been developed. Functional variations concern the carboxylic group and/or the 4 position of phenyl group. Most of the compounds prepared have been tested with regard to their antimycobacterial activity but the activities found are medium or low ones. However, (1-phenyltetrazol-5-ylthio)acetic acid is better than the antituberculotic isoniazid in the activity to Mycobacterium avium.