Collect. Czech. Chem. Commun. 1990, 55, 1278-1289

Potential cerebral stimulants: Esters of 2-dimethylaminoethanol with some lipophilic carboxylic acids

Miroslav Protivaa, Vladimír Valentaa, Zdeňka Kopicováa, Juraj Lukáčb, Jiří Holubeka and Ivan Krejčía

a Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
b Léčiva, national enterprise, 109 02 Prague 10, Dolní Měcholupy 130


2-Dimethylaminoethyl esters of 2,2-dimethylpropanoic, heptanoic, octanoic, decanoic, hexadecanoic, cyclopentylacetic, cycloheptylacetic, 2-cyclopentylhexanoic, (4-chlorophenoxy)fumaric, and 2-(4-chlorophenoxy)succinic acid were prepared by reactions of the acid chlorides with 2-dimethylaminoethanol and were transformed to crystalline salts for pharmacological testing. The ester IX (hydrogen fumarate V⁄FB-14 005) was found to antagonize significantly halothan amnesia in rats and the ester X (hydrogen fumarate V⁄FB-14004) proved to be an anticholinergic spasmolytic agent.