Collect. Czech. Chem. Commun. 1980, 45, 294-297

Synthesis of analogues of the melanocyte-stimulating hormone release-inhibiting factor containing 2-oxoimidazolidine-1-carboxylic acid

Evžen Kasafíreka, Ivan Krejčí and Vladimír Feltb

a Research Institute for Pharmacy and Biochemistry, 130 60 Prague
b Research Institute for Endocrinology, 116 94 Prague


2-Oxoimidazolidine-1-carbonyl-leucyl-glycine amide (I), 2-oxoimidazolidine-1-carbonyl-leucyl-β-alanine amide (II), and 2-oxoimidazolidine-1-carbonyl-leucine amide (III) were synthesized by the acylation of corresponding dipeptide or amino-acid esters with 2-oxoamidazolidine-1-carbonyl chloride and following ammonolysis. Analogues I and II, containing 2-oxoimidazolidine-1-carboxylic acid instead of proline, exhibited the antiamnestic activity in the doses of 1 mg per kg subcutaneously, III was without effect.