Collect. Czech. Chem. Commun. 1983, 48, 2862-2873

Vasopressin analogues with effect on central nervous system: Synthesis and biological properties

František Brtníka, Ivan Krejčíb, Běla Kupkováb, Pavel Hrbasa, Jana Škopkováa, Tomislav Bartha and Karel Jošta

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Research Institute for Pharmacy and Biochemistry, 194 09 Prague 9


Synthesis of four vasopressin analogues which do not contain the glycinamine residue in position 9 and have a basic non-coded amino acid in position 8 is described. All the analogues exhibit very low endocrine activities and are effective in the passive avoidance test.