Collect. Czech. Chem. Commun. 1992, 57, 212-215

Preparation of Some Substituted 9,10-Dihydro-1-hydroxy-9-oxoacridine Derivatives

Stanislav Rádl and Lenka Kovářová

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


In connection with our research into antibacterial fluoroquinolones of a general formula I we were interested in similar 1-hydroxy-acridines II. Our synthetic strategy was based on a recent finding that ethyl 2-(1,4-dihydro-4-oxoquinolin-2-yl) acetate reacted at 180 °C with diethyl ethoxymethylene-malonate providing diethyl 9,10-dihydro-1-hydroxy-9-oxoacridine-2,4-dicarboxylate.