Collect. Czech. Chem. Commun. 2009, 74, 1035-1059
https://doi.org/10.1135/cccc2009042
Published online 2009-07-07 15:15:08

Synthesis of (purin-6-yl)acetates and their transformations to 6-(2-hydroxyethyl)- and 6-(carbamoylmethyl)purines

Zbyněk Hasník, Radek Pohl, Blanka Klepetářová and Michal Hocek*

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Gilead Sciences & IOCB Research Center, Flemingovo nám. 2, CZ-166 10 Prague 6, Czech Republic

Individual author index pages


Other CCCC articles of these authors

  • Michal Česnek, Michal Hocek and Antonín Holý
    Cross-coupling reactions of 2-amino-6-halopurine derivatives with organometallic reagents leading to 6-alkylated purine acyclic nucleotide analogues
    Symposium Series 1999, Vol. 2, pp. 255–256 [Abstract]
    Published online 2016-05-08 23:31:50
  • Michal Hocek, Martina Havelková, Dalimil Dvořák, Antonín Holý and Ivan Votruba
    Synthesis of 6-phenylpurine bases and nucleosides by Suzuki–Miyaura cross-coupling reactions of 6-chloropurines with substituted phenylboronic acids
    Symposium Series 1999, Vol. 2, pp. 27–30 [Abstract]
    Published online 2016-05-08 20:40:17
  • Pavel Turek, Michal Hocek and Martin Kotora
    [2+2+2]-co-Cyclotrimerization of 6-alkynylpurines with diynes: A method for preparation 6-arylpurines
    Symposium Series 2002, Vol. 5, pp. 389–390 [Abstract]
    Published online 2016-01-25 20:52:00
  • Michal Hocek
    Synthesis of carba-analogues of myoseverin
    Symposium Series 2002, Vol. 5, pp. 324–325 [Abstract]
    Published online 2016-01-25 20:42:22
  • Michal Hocek, Dalimil Dvořák and Martina Havelková
    Covalently linked purine dimers or trimers and purine–pyrimidine conjugates – analogues of nucleobase-pairs or triplets
    Symposium Series 2002, Vol. 5, pp. 36–37 [Abstract]
    Published online 2016-01-25 20:38:15
  • Milan Vrabel, Ivan Rosenberg and Michal Hocek
    Synthesis of modified nucleosides and oligonucleotides bearing bipyridine or phenanthroline ligands
    Symposium Series 2005, Vol. 7, pp. 485–486 [Abstract]
    Published online 2015-11-08 11:58:56
  • Petr Novák, Michal Hocek and Martin Kotora
    Synthesis of C-arylribosides by catalytic [2+2+2]-cyclotrimerization reaction
    Symposium Series 2005, Vol. 7, pp. 445–446 [Abstract]
    Published online 2015-11-08 11:57:49
  • Martin Kuchař and Michal Hocek
    Synthesis of purines bearing functionalized C-substituents by nucleophilic additions to 6-ethynyl- or 6-vinylpurines
    Symposium Series 2005, Vol. 7, pp. 423–424 [Abstract]
    Published online 2015-11-08 11:57:11
  • Petr Kočalka, Markéta Rinnová, Václav Vaněk, Dominik Rejman, Ivan Votruba, Ivana Tomečková, Šárka Králíková, Magdalena Petrová, Ondřej Páv, Radek Pohl, Miloš Buděšínský, Radek Liboska, Zdeněk Točík and Ivan Rosenberg
    Novel nucleoside phosphonic acids-based inhibitors of thymidine phosphorylase
    Symposium Series 2005, Vol. 7, pp. 415–416 [Abstract]
    Published online 2015-11-08 11:56:57
  • Kateřina Hořejší, Radek Pohl and Antonín Holý
    Tricyclic etheno analogs of purines derived from 2-amino-6-chloropurine
    Symposium Series 2005, Vol. 7, pp. 403–404 [Abstract]
    Published online 2015-11-08 11:56:30
  • Karel Pomeisl, Ivan Votruba, Antonín Ho and Radek Pohl
    Pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives: Their syntheses and utilization as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
    Symposium Series 2005, Vol. 7, pp. 291–295 [Abstract]
    Published online 2015-11-08 11:54:12
  • Pavel Turek, Michal Hocek and Martin Kotora
    Cocyclotrimerization of 6-alkynylpurines with diynes as a novel approach to biologically active 6-arylpurines
    Symposium Series 2005, Vol. 7, pp. 279–282 [Abstract]
    Published online 2015-11-08 11:53:57
  • Jan Štambaský, Pavel Kočovský and Michal Hocek
    Towards a novel approach to C-nucleosides
    Symposium Series 2005, Vol. 7, pp. 277–278 [Abstract]
    Published online 2015-11-08 11:53:52
  • Peter Šilhár, Radek Pohl, Ivan Votruba and Michal Hocek
    Synthesis and transformations of 6-(hydroxymethyl)purines
    Symposium Series 2005, Vol. 7, pp. 221–224 [Abstract]
    Published online 2015-11-08 11:52:45
  • Petr Čapek and Michal Hocek
    Synthesis of (purin-6-yl)amino acids
    Symposium Series 2005, Vol. 7, pp. 217–220 [Abstract]
    Published online 2015-11-08 11:52:40
  • Michal Hocek and Dana Hocková
    Regioselective cross-coupling reactions in the synthesis of multisubstituted purine bases and nucleosides
    Symposium Series 2005, Vol. 7, pp. 213–216 [Abstract]
    Published online 2015-11-08 11:52:35
  • Radek Pohl, Dominik Rejman, Petr Kočalka and Ivan Rosenberg
    Pyrrolidine nucleotide analogues – conformation study
    Symposium Series 2005, Vol. 7, pp. 165–166 [Abstract]
    Published online 2015-11-08 11:51:48
  • Dominik Rejman, Petr Kočalka, Radek Pohl and Ivan Rosenberg
    Synthesis of 4'-N pyrrolidine nucleosides, nucleotides, and oligonucleotides
    Symposium Series 2005, Vol. 7, pp. 159–163 [Abstract]
    Published online 2015-11-08 11:51:43
  • Ivan Rosenberg, Ivan Barvik, Miloš Buděšínský, Petr Kočalka, Šárka Králíková, Radek Liboska, Ondřej Pačes, Ondřej Páv, Magdalena Petrová, Radek Pohl, Martina Pressová, Dominik Rejman, Ivan Votruba and Zdeněk Točík
    Nucleoside phosphonic acids and related oligonucleotides: Structural diversity vs biological properties
    Symposium Series 2005, Vol. 7, pp. 153–157 [Abstract]
    Published online 2015-11-08 11:51:38
  • Martin Štefko and Michal Hocek
    A modular methodology for the synthesis of 3- and 4-substituted benzene and aniline C-ribonucleosides
    Symposium Series 2008, Vol. 10, pp. 455–456 [Abstract]
    Published online 2015-10-30 18:45:05
  • Ondřej Sedláček, Radek Pohl and Antonín Holý
    Synthesis of 8-C-substituted 2,6-diaminopurine acyclic nucleoside phosphonates by Negishi cross-coupling
    Symposium Series 2008, Vol. 10, pp. 449–450 [Abstract]
    Published online 2015-10-30 18:44:50
  • Jan Riedl and Michal Hocek
    Synthesis of modified fluorescent nucleosides
    Symposium Series 2008, Vol. 10, pp. 442–443 [Abstract]
    Published online 2015-10-30 18:44:40
  • Radek Pohl, Miloš Buděšínský, Dominik Rejman, Petr Kočalka and Ivan Rosenberg
    Conformation of pyrrolidine ring in pyrrolidine nucleotide analogues
    Symposium Series 2008, Vol. 10, pp. 435–436 [Abstract]
    Published online 2015-10-30 18:44:27
  • Lubica Kalachova and Michal Hocek
    Synthesis of modified nucleosides and nucleoside triphosphates bearing oligopyridine ligands
    Symposium Series 2008, Vol. 10, pp. 366–368 [Abstract]
    Published online 2015-10-30 18:42:13
  • Zbyněk Hasník and Michal Hocek
    Synthesis of (purin-6-yl)acetates and their transformations
    Symposium Series 2008, Vol. 10, pp. 352–354 [Abstract]
    Published online 2015-10-30 18:41:46
  • Igor Čerňa and Michal Hocek
    Direct C–H arylation of purines and purine nucleosides
    Symposium Series 2008, Vol. 10, pp. 327–329 [Abstract]
    Published online 2015-10-30 18:40:48
  • Ondřej Baszczyňski, Antonín Holý, Martin Dračínský and Blanka Klepetářová
    Synthesis of N9-(3-fluoro-2-phosphonomethoxypropyl) (FPMP) derivatives of N6-substituted adenines and 2,6-diaminopurines
    Symposium Series 2008, Vol. 10, pp. 315–316 [Abstract]
    Published online 2015-10-30 18:40:22
  • Jan Bárta and Michal Hocek
    Modular synthesis of 5-substituted thiophen-2-yl C-2'-deoxyribonucleosides
    Symposium Series 2008, Vol. 10, pp. 313–314 [Abstract]
    Published online 2015-10-30 18:40:16
  • Karel Pomeisl, Antonín Holý, Ivan Votruba, Radim Nencka and Radek Pohl
    Facile syntheses of pyrimidine acyclic nucleoside phosphonates and their potential evaluation for biomedical applications
    Symposium Series 2008, Vol. 10, pp. 201–205 [Abstract]
    Published online 2015-10-30 18:37:39
  • Milan Vrabel and Michal Hocek
    Synthesis of modified nucleosides, nucleotides and oligonucleotides bearing metal complexes
    Symposium Series 2008, Vol. 10, pp. 182–185 [Abstract]
    Published online 2015-10-30 18:37:15
  • Hana Cahová, Luděk Havran, Petra Brázdilová, Hana Pivoňková, Miroslav Fojta and Michal Hocek
    Aminophenyl- and nitrophenyl-labeled DNA. Synthesis by polymerase incorporation of nucleoside triphosphates and electrochemical properties
    Symposium Series 2008, Vol. 10, pp. 178–181 [Abstract]
    Published online 2015-10-30 18:37:09
  • Nicolas Joubert, Jan Bárta, Milan Urban and Michal Hocek
    Modular methodology for the syntheses of various aryl C-2'-deoxyribonucleosides
    Symposium Series 2008, Vol. 10, pp. 173–177 [Abstract]
    Published online 2015-10-30 18:37:03
  • Petr Novák, Michal Hocek and Martin Kotora
    New approaches to synthesis of C-deoxyribosides starting from C-alkynyldeoxyribosides
    Symposium Series 2008, Vol. 10, pp. 168–172 [Abstract]
    Published online 2015-10-30 18:36:57
  • Michal Hocek, Peter Šilhár, Martin Kuchař, Zbyněk Hasník and Vítězslav Bambuch
    Purine bases and nucleosides bearing functionalized C-substituents in position 6. Synthesis and biological activities
    Symposium Series 2008, Vol. 10, pp. 164–167 [Abstract]
    Published online 2015-10-30 18:36:52
  • Michal Tichý and Michal Hocek
    Synthesis of 4-(het)aryl pyrimido[4,5-b]indole ribonucleosides
    Symposium Series 2011, Vol. 12, pp. 475–476 [Abstract]
    Published online 2015-08-20 10:24:59
  • Dominik Rejman and Radek Pohl
    Synthesis of PME derivatives of nucleobases with conformation locked via pyrrolidine ring
    Symposium Series 2011, Vol. 12, pp. 446–447 [Abstract]
    Published online 2015-08-20 10:23:57
  • Veronika Raindlová and Michal Hocek
    Direct enzymatic synthesis of aldehyde-functionalized DNA and its conjugation with hydrazines and amines
    Symposium Series 2011, Vol. 12, pp. 441–443 [Abstract]
    Published online 2015-08-20 10:23:46
  • Hana Pivoňková, Kateřina Němcová, Petra Horáková, Luděk Havran, Hana Macíčková-Cahová, Michal Hocek and Miroslav Fojta
    Tail labelled oligonucleotide probes for the detection of DNA-protein interactions
    Symposium Series 2011, Vol. 12, pp. 435–437 [Abstract]
    Published online 2015-08-20 10:23:34
  • Magdalena Petrová, Miloš Buděšínský, Blanka Klepetářová and Ivan Rosenberg
    Synthesis and structural assignment of novel 5'-epimeric 3'-deoxy-3',4'-didehydronucleoside-5'-C-phosphonates
    Symposium Series 2011, Vol. 12, pp. 430–432 [Abstract]
    Published online 2015-08-20 10:23:23
  • Pavel Kielkowski and Michal Hocek
    Polymerase synthesis of modified DNA containing cytosine in major groove
    Symposium Series 2011, Vol. 12, pp. 359–360 [Abstract]
    Published online 2015-08-20 10:19:01
  • Lubica Kalachova and Michal Hocek
    Synthesis of nucleotides bearing oligopyridine ligands and their incorporation into DNA
    Symposium Series 2011, Vol. 12, pp. 357–358 [Abstract]
    Published online 2015-08-20 10:18:56
  • Miroslava Čerňová and Michal Hocek
    Dichotomy in regioselectivity of Pd-catalyzed direct C–H arylation of protected uracils
    Symposium Series 2011, Vol. 12, pp. 314–316 [Abstract]
    Published online 2015-08-20 10:12:11
  • Jan Bárta and Michal Hocek
    Modular synthesis of 5-substituted thiophene and furan C-nucleosides and their analogues
    Symposium Series 2011, Vol. 12, pp. 300–301 [Abstract]
    Published online 2015-08-20 10:11:36
  • Jana Balintová, Luděk Havran, Miroslav Fojta and Michal Hocek
    Synthesis of nucleosides and nucleoside triphosphates bearing anthraquinone substituents as redox probes and their enzymatic incorporation to DNA
    Symposium Series 2011, Vol. 12, pp. 297–299 [Abstract]
    Published online 2015-08-20 10:11:31
  • Jan Riedl and Michal Hocek
    Synthesis of biaryl-substituted fluorescent nucleosides and nucleoside triphosphates and their incorporation to DNA
    Symposium Series 2011, Vol. 12, pp. 233–235 [Abstract]
    Published online 2015-08-20 10:02:23
  • Pavla Perlíková, Petr Nauš, Aurelie Bourderioux and Michal Hocek
    Hetaryl derivatives of 7-deazapurine ribonucleosides: potent cytostatic agents
    Symposium Series 2011, Vol. 12, pp. 194–198 [Abstract]
    Published online 2015-08-20 10:00:49
  • Tomáš Kubelka, Martin Štefko, Jan Bárta, Nicolas Joubert, Milan Urban, Hubert Chapuis and Michal Hocek
    Development of a general and modular approach to C-nucleosides
    Symposium Series 2011, Vol. 12, pp. 180–183 [Abstract]
    Published online 2015-08-20 10:00:32
  • Miroslav Fojta, Luděk Havran, Petra Horáková, Hana Pivoňková, Pavel Kostečka, Hana Macíčková, Veronika Raindlová, Milan Vrabel and Michal Hocek
    Redox labelling of nucleic acids for analyzing nucleotide sequences and monitoring DNA-protein interactions
    Symposium Series 2011, Vol. 12, pp. 155–158 [Abstract]
    Published online 2015-08-20 09:59:54
  • Michal Hocek, Hana Macíčková-Cahová, Pavel Kielkowski, Veronika Raindlová, Lubica Kalachova, Jan Riedl, Jana Balintová and Petra Ménová
    Polymerase construction of base-modified DNA for chemical biology
    Symposium Series 2011, Vol. 12, pp. 152–154 [Abstract]
    Published online 2015-08-20 09:59:48
  • Zuzana Vaníková and Michal Hocek
    Polymerase synthesis of new photocaged DNA
    Symposium Series 2014, Vol. 14, pp. 392–393 [Abstract]
    Published online 2015-07-06 23:09:39
  • Michal Tichý and Michal Hocek
    Synthesis and biological activity of thiophene fused 7-deazapurine ribonucleosides
    Symposium Series 2014, Vol. 14, pp. 385–386 [Abstract]
    Published online 2015-07-06 23:09:23
  • Anna Simonova, Luděk Havran, Miroslav Fojta and Michal Hocek
    New oxidative labels for electrochemical detection of DNA
    Symposium Series 2014, Vol. 14, pp. 365–366 [Abstract]
    Published online 2015-07-06 23:08:32
  • Lenka Poštová Slavětínská, Radek Pohl and Dominik Rejman
    Conformation analysis of nucleoside analogues containing selenium and tellurium in five-membered pseudosugar ring
    Symposium Series 2014, Vol. 14, pp. 354–355 [Abstract]
    Published online 2015-07-06 23:08:08
  • Radek Pohl, Lenka Poštová Slavětínská and Dominik Rejman
    Pyrrolidine nucleotides conformationally constrained via hydrogen bonding
    Symposium Series 2014, Vol. 14, pp. 352–353 [Abstract]
    Published online 2015-07-06 23:08:03
  • Petr Orság, Hana Pivoňková, Jan Riedl, Michal Hocek and Miroslav Fojta
    Utilisation of enzymatic labelling with 4-aminophtalimide and 4-hydroxybenzylideneimidazolinone fluorescent derivates for monitoring of DNA-protein interaction
    Symposium Series 2014, Vol. 14, pp. 340–341 [Abstract]
    Published online 2015-07-06 23:07:27
  • Petra Ménová and Michal Hocek
    Preparation of modified oligonucleotides by nicking enzyme amplification reaction
    Symposium Series 2014, Vol. 14, pp. 324–325 [Abstract]
    Published online 2015-07-06 23:06:55
  • Michaela Mačková and Michal Hocek
    Vinyl-modified DNA and its cleavage by restriction endonucleases
    Symposium Series 2014, Vol. 14, pp. 318–319 [Abstract]
    Published online 2015-07-06 23:06:39
  • Pavel Kielkowski and Michal Hocek
    Competitive incorporations of modified versus natural nucleotides by DNA polymerases
    Symposium Series 2014, Vol. 14, pp. 295–296 [Abstract]
    Published online 2015-07-06 23:05:36
  • Miroslav Fojta, Aleš Daňhel, Petra Horáková, Medard Plucnara, Hana Pivoňková, Luděk Havran, Pavlína Vidláková, Veronika Raindlová, Jana Balintová, Hana Macíčková-Cahová and Michal Hocek
    Electrochemical analysis of DNA using switchable redox moieties
    Symposium Series 2014, Vol. 14, pp. 264–266 [Abstract]
    Published online 2015-07-06 23:04:13
  • Jitka Daďová, Petr Orság, Radek Pohl, Marie Brázdová, Miroslav Fojta and Michal Hocek
    Study of DNA-protein interactions by cross-link formation using aqueous Michael addition
    Symposium Series 2014, Vol. 14, pp. 240–241 [Abstract]
    Published online 2015-07-06 23:03:09
  • Jana Balintová, Marie Brázdová, Luděk Havran, Miroslav Fojta and Michal Hocek
    Redox labeling and redox coding of nucleic acids
    Symposium Series 2014, Vol. 14, pp. 229–230 [Abstract]
    Published online 2015-07-06 23:02:33
  • Jana Balintová, Jitka Daďová, Pavel Kielkowski, Petra Ménová, Zuzana Vaníková, Jan Riedl, Veronika Raindlová, Miroslav Fojta and Michal Hocek
    Polymerase synthesis of base-modified DNA: new methods and new applications
    Symposium Series 2014, Vol. 14, pp. 66–67 [Abstract]
    Published online 2015-07-06 22:57:12
  • Petr Jansa*, Petr Špaček, Ivan Votruba, Petra Břehová, Martin Dračínský, Blanka Klepetářová and Zlatko Janeba
    Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the “click” protocol
    2011, Vol. 76, Issue 9, pp. 1121–1131 [Abstract]
  • Petr Nauš, Pavla Perlíková, Radek Pohl and Michal Hocek*
    Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2′-C-methylribonucleosides, arabinonucleosides and 2′-deoxy-2′-fluoroarabinonucleosides
    2011, Vol. 76, Issue 8, pp. 957–988 [Abstract]
  • Aleš Marek, Blanka Klepetářová and Tomáš Elbert*
    The introduction of a double bond on the steroid skeleton – The preparation of enol silyl ether derivatives from vicinal diols
    2011, Vol. 76, Issue 5, pp. 443–456 [Abstract]
  • Louis Adriaenssens, Lukáš Severa, Jan Vávra, Tereza Šálová, Jakub Hývl, Martina Čížková, Radek Pohl, David Šaman and Filip Teplý*
    Bio- and air-tolerant carbon–carbon bond formations via organometallic ruthenium catalysis
    2009, Vol. 74, Issue 7-8, pp. 1023–1034 [Abstract] [Full text pdf]
  • Dominik Rejman*, Petr Kočalka, Radek Pohl, Zdeněk Točík and Ivan Rosenberg*
    Synthesis and hybridization of oligonucleotides modified at AMP sites with adenine pyrrolidine phosphonate nucleotides
    2009, Vol. 74, Issue 6, pp. 935–955 [Abstract]
  • Petr Nauš, Martin Kuchař and Michal Hocek*
    Cytostatic and Antiviral 6-Arylpurine Ribonucleosides IX. Synthesis and Evaluation of 6-Substituted 3-Deazapurine Ribonucleosides
    2008, Vol. 73, Issue 5, pp. 665–678 [Abstract] [Full text pdf]
  • Michal Hocek*, Peter Šilhár and Radek Pohl
    Cytostatic and Antiviral 6-Arylpurine Ribonucleosides VIII. Synthesis and Evaluation of 6-Substituted Purine 3'-Deoxyribonucleosides
    2006, Vol. 71, Issue 10, pp. 1484–1496 [Abstract]
  • Peter Šilhár, Radek Pohl, Ivan Votruba, Blanka Klepetářová and Michal Hocek*
    Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl-2-(hydroxymethyl)purine Bases and Nucleosides
    2006, Vol. 71, Issue 6, pp. 788–803 [Abstract]
  • Karel Pomeisl*, Ivan Votruba, Antonín Holý and Radek Pohl
    Syntheses of Base and Side-Chain Modified Pyrimidine 1-[2-(Phosphonomethoxy)propyl] Derivatives as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-Lymphoma
    2006, Vol. 71, Issue 4, pp. 595–624 [Abstract]
  • Silvie Vrbovská*, Antonín Holý, Radek Pohl and Milena Masojídková
    Bifunctional Acyclic Nucleoside Phosphonates. 1. Symmetrical 1,3-Bis[(phosphonomethoxy)propan-2-yl] Derivatives of Purines and Pyrimidines
    2006, Vol. 71, Issue 4, pp. 543–566 [Abstract]
  • Kateřina Hořejší, Radek Pohl and Antonín Holý*
    Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts
    2006, Vol. 71, Issue 1, pp. 77–90 [Abstract]
  • Peter Šilhár, Radek Pohl, Ivan Votruba and Michal Hocek*
    Synthesis of 2-Substituted 6-(Hydroxymethyl)purine Bases and Nucleosides
    2005, Vol. 70, Issue 10, pp. 1669–1695 [Abstract]
  • Karel Pomeisl*, Radek Pohl, Antonín Holý and Ivan Votruba
    Simple Transformation of Thymine 1-[3-Hydroxy-2-(phosphonomethoxy)propyl] Derivatives to Their 1-[3-Fluoro-2-(phosphonomethoxy)propyl] Counterparts
    2005, Vol. 70, Issue 9, pp. 1465–1481 [Abstract]
  • Pavel Turek, Martin Kotora*, Michal Hocek* and Ivan Votruba
    Novel Method for Preparation of Highly Substituted 6-Arylpurines by Reactions of 6-Alkynylpurines with Zirconacyclopentadienes
    2005, Vol. 70, Issue 3, pp. 339–349 [Abstract]
  • Blanka Klepetářová, Jan Čejka, Bohumil Kratochvíl, Svetlana Pakhomova, Ivana Císařová, Ladislav Cvak and Alexandr Jegorov*
    Interesting Solvent Area in Crystal Structures of Two Natural Ergot Alkaloids
    2005, Vol. 70, Issue 1, pp. 41–50 [Abstract]
  • Petr Nauš, Ivan Votruba and Michal Hocek*
    Covalent Analogues of DNA Base-Pairs and Triplets VII. Synthesis and Cytostatic Activity of Bis(purin-6-yl)acetylene and -diacetylene Nucleosides
    2004, Vol. 69, Issue 10, pp. 1955–1970 [Abstract]
  • Michal Hocek*, Dana Hocková and Jan Štambaský
    Cytostatic 6-Arylpurine Nucleosides V. Synthesis of 8-Substituted 6-Phenylpurine Ribonucleosides
    2003, Vol. 68, Issue 5, pp. 837–848 [Abstract]
  • Michal Hocek*, Hana Dvořáková and Ivana Císařová
    Covalent Analogues of DNA Base-Pairs and Triplets V. Synthesis of Purine-Purine and Purine-Pyrimidine Conjugates Connected by Diverse Types of Acyclic Carbon Linkages
    2002, Vol. 67, Issue 10, pp. 1560–1578 [Abstract]
  • Michal Hocek*, Irena G. Stará, Ivo Starý and Hana Dvořáková
    Covalent Analogues of DNA Base-Pairs and Triplets IV. Synthesis of Trisubstituted Benzenes Bearing Purine and/or Pyrimidine Rings by Cyclotrimerization of 6-Ethynylpurines and/or 5-Ethynyl-1,3-dimethyluracil
    2002, Vol. 67, Issue 8, pp. 1223–1235 [Abstract]
  • Michal Hocek*, Antonín Holý and Hana Dvořáková
    Cytostatic 6-Arylpurine Nucleosides IV. Synthesis of 2-Substituted 6-Phenylpurine Ribonucleosides
    2002, Vol. 67, Issue 3, pp. 325–335 [Abstract]
  • Michal Hocek*, Antonín Holý, Ivan Votruba and Hana Dvořáková
    Cytostatic 6-Arylpurine Nucleosides III. Synthesis and Structure-Activity Relationship Study in Cytostatic Activity of 6-Aryl-, 6-Hetaryl- and 6-Benzylpurine Ribonucleosides
    2001, Vol. 66, Issue 3, pp. 483–499 [Abstract]
  • Michal Hocek*, Antonín Holý, Ivan Votruba and Hana Dvořáková
    Cytostatic 6-Arylpurine Nucleosides II. Synthesis of Sugar-Modified Derivatives: 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-Deoxy-β-D-ribofuranosyl)- and 9-(2,3-Dihydroxypropyl)-6-phenylpurines
    2000, Vol. 65, Issue 11, pp. 1683–1697 [Abstract]
  • Radek Pohl, Jan Sýkora, Petr Maloň, Stanislav Böhm*, Bohumil Kratochvíl and Josef Kuthan
    Sterically Crowded Heterocycles. XIII. An Insight Into the Absolute Stereochemistry of Atropisomeric (Z)-3-(Imidazo[1,2-a]pyridin-3-yl)prop-2-en-1-ones
    2000, Vol. 65, Issue 10, pp. 1643–1652 [Abstract]
  • Michal Česnek, Michal Hocek* and Antonín Holý
    Synthesis of Acyclic Nucleotide Analogues Derived from 2-Amino-6-C-substituted Purines via Cross-Coupling Reactions of 2-Amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with Diverse Organometallic Reagents
    2000, Vol. 65, Issue 8, pp. 1357–1373 [Abstract]
  • Robert Klvaňa, Radek Pohl, Jan Pawlas, Jan Čejka, Hana Dvořáková, Richard Hrabal, Stanislav Böhm*, Bohumil Kratochvíl and Josef Kuthan
    Sterically Crowded Heterocycles. XII. Atropisomerism of (1-Aryl-3,5-diphenyl-1H-pyrrol-2-yl)(phenyl)methanones
    2000, Vol. 65, Issue 5, pp. 651–666 [Abstract]
  • Stanislav Böhm*, Radek Pohl and Josef Kuthan
    Sterically Crowded Heterocycles. XI. A Semiempirical Prediction of Enantiomerization Barriers for Substituted (Z)-3-(Imidazo[1,2-a]pyridin-3-yl)-1-phenylprop-2-en-1-ones
    1999, Vol. 64, Issue 11, pp. 1761–1769 [Abstract]
  • Radek Pohl, Stanislav Böhm and Josef Kuthan*
    Sterically Crowded Heterocycles. X. A New Mechanistic Approach to the Ferricyanide Oxidation of 4,6'-Disubstituted 1-(Pyridin-2'-yl)-2,6-diphenylpyridinium Salts
    1999, Vol. 64, Issue 8, pp. 1274–1294 [Abstract]
  • Michal Hocek* and Antonín Holý
    Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues
    1999, Vol. 64, Issue 2, pp. 229–241 [Abstract]
  • Michal Hocek, Milena Masojídková and Antonín Holý
    Synthesis of Acyclic Nucleotide Analogues Derived from 6-Hetarylpurines via Cross-Coupling Reactions of 9-[2-(Diethoxyphosphonylmethoxy)ethyl]-6-iodopurine with Hetaryl Organometallic Reagents
    1997, Vol. 62, Issue 1, pp. 136–146 [Abstract]
  • Michal Hocek and Antonín Holý
    Acyclic nucleotide analogues derived from 6-(1-aminoalkyl)purines
    1996, Vol. 61, Special Issue, pp. S55–S58 [Abstract]
  • Michal Hocek, Milena Masojídková, Antonín Holý, Graciela Andrei, Robert Snoeck, Jan Balzarini and Erik De Clercq
    Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines
    1996, Vol. 61, Issue 10, pp. 1525–1537 [Abstract]
  • Michal Hocek and Antonín Holý
    A Facile Synthesis of 6-Cyanopurine Bases
    1995, Vol. 60, Issue 8, pp. 1386–1389 [Abstract]
  • Radek Pohl, Viktor Prutianov and Svatava Smrčková-Voltrová
    Nucleophilic Substitution in a Series of 4-Nitronicotinic Acid 1-Oxide Derivatives
    1995, Vol. 60, Issue 7, pp. 1170–1177 [Abstract]
  • Michal Hocek, Milena Masojídková and Antonín Holý
    Synthesis of Acyclic Nucleotide Analogues Derived from 2-(Aminomethyl)adenine and 2-(Aminomethyl)hypoxanthine
    1995, Vol. 60, Issue 5, pp. 875–882 [Abstract]
  • Stanislav Böhm, Michal Hocek, Jan Němeček, Vladimír Havlíček and Josef Kuthan
    Preparation and Spectroscopic Properties of Spirocyclic 1-Methyl-2,4,4,6-tetraaryl-1,4-dihydropyridines
    1994, Vol. 59, Issue 5, pp. 1105–1114 [Abstract]
  • Stanislav Böhm, Michal Hocek, Stanislav Nešpůrek and Josef Kuthan
    Photocolouration of 2,4,4,6-Tetraaryl-1,4-dihydropyridines: A Semiempirical Quantum Chemical Study
    1994, Vol. 59, Issue 2, pp. 262–272 [Abstract]