Collect. Czech. Chem. Commun. 1994, 59, 1105-1114

Preparation and Spectroscopic Properties of Spirocyclic 1-Methyl-2,4,4,6-tetraaryl-1,4-dihydropyridines

Stanislav Böhma, Michal Hoceka, Jan Němečekb, Vladimír Havlíčekb and Josef Kuthana

a Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic
b Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic


1,5-Diones Ib - Ie were converted to spirocyclic 1,4-dihydropyridines IIb - IIe by treatment with methanolic methylamine. The starting diketones Ib - Ie were obtained from corresponding acetophenones 4-X-C6H4COMe and fluorenone with sodium amide except of If where only ketone III and 1,4-dione IV were isolated. Molecular spectra (UV-VIS, NMR, IR and MS) of compounds Ib - Ie, IIa - IIe, III, and IV were assigned and interpreted.