Collect. Czech. Chem. Commun. 1995, 60, 1386-1389

A Facile Synthesis of 6-Cyanopurine Bases

Michal Hocek and Antonín Holý

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic


A facile method of preparation of 6-cyanopurine bases from commercially available 6-chloropurines is reported. The 6-chloropurines were selectively protected by THP-functions and the protected derivatives reacted smoothly with tetraethylammonium cyanide and DABCO to give 6-cyanopurine derivatives that were easily deprotected to afford the title compounds.