Collect. Czech. Chem. Commun. 1995, 60, 1380-1385

NMR Determination of the Structure of Peracetylated Icariside B2 from Veratrum Lobelianum BERNH.

Václav Suchýa, Miloš Buděšínskýb, Karel Ubikb, Daniel Grančaic and Vlasta Földešiovác

a Department of Natural Drugs, University of Veterinary Medicine and Pharmacy, 612 42 Brno, Czech Republic
b Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
c Department of Pharmacognosy and Botany, Comenius University, 832 32 Bratislava, Slovak Republic


rel(1S,4S,5R)-3,3,5-Trimethyl-4-[( 1E)-3-oxo-1-butenyl]-4,5-epoxy-cyclohexyl-O-β-D-glucopyranoside (I) was isolated from the aerial part of Veratrum lobelianum BERNH. The structure was derived mainly from detailed analysis of 1H and 13C NMR spectra of its acetylated derivative II. Compound I has been already reported under the name icariside B2in Epimedium grandiflorum MORR. var. thunbergianum (MIQ.) NAKAI.