Collect. Czech. Chem. Commun. 2009, 74, 347-362
https://doi.org/10.1135/cccc2008072
Published online 2009-02-18 15:00:16

Identification, synthesis and structural determination of some impurities of candesartan cilexetil

Jaroslav Havlíčeka,*, Zuzana Mandelováa, Ruediger Weisemannb, Ivo Střeleca, Lukáš Plačeka and Stanislav Rádla

a Zentiva, U kabelovny 130, 102 37 Prague 10, Czech Republic
b Bruker BioSpin GmbH, Silberstreifen, 76287 Rheinstetten, Germany

Individual author index pages


Other CCCC articles of these authors

  • Stanislav Rádl*, Jan Stach, Josef Černý and Ondřej Klecán
    An efficient synthesis of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine, a key intermediate in the licofelone synthesis
    2009, Vol. 74, Issue 6, pp. 1011–1022 [Abstract]
  • Jan Stach*, Jaroslav Havlíček, Lukáš Plaček and Stanislav Rádl
    Synthesis of Some Impurities and/or Degradation Products of Atorvastatin
    2008, Vol. 73, Issue 2, pp. 229–246 [Abstract]
  • Stanislav Rádl*, Ondřej Klecán, Robert Klvaňa and Jaroslav Havlíček
    A New Synthesis of Rizatriptan Based on Radical Cyclization
    2008, Vol. 73, Issue 1, pp. 116–126 [Abstract]
  • Michaela Hamerníková*, Jaroslav Havlíček, Romana Bláhová, Helena Pospíšilová, Hana Votavová and Karel Kefurt
    6-Amino-2,6-dideoxy- or -2,3,6-trideoxyhexono-1,6-lactams: Synthesis and Conformation
    2004, Vol. 69, Issue 4, pp. 867–884 [Abstract]
  • Stanislav Rádl* and Iva Obadalová
    Utilization of Aromatic Denitrocyclization Reaction for the Synthesis of 3-Unsubstituted 1,4-Dihydroquinolin-4-one Derivatives
    2004, Vol. 69, Issue 4, pp. 822–832 [Abstract]
  • Michaela Hamerníková*, Jaroslav Havlíček, Hana Votavová and Karel Kefurt
    Synthesis and Conformation of 6-Amino-3,6-dideoxyhexono-1,6-lactams
    2002, Vol. 67, Issue 5, pp. 622–644 [Abstract]
  • Ivan Stibor*, Martina Růžičková, Rostislav Krátký, Michal Vindyš, Jaroslav Havlíček, Evguenni Pinkhassik, Pavel Lhoták, Asiya R. Mustafina, Yuliya E. Morozova, Ella Kh. Kazakova and Valentina P. Gubskaya
    New Calix[4]arene-Based Amides - Their Synthesis, Conformation, Complexation
    2001, Vol. 66, Issue 4, pp. 641–662 [Abstract]
  • Stanislav Rádl*, Petr Hezký, Petr Konvička and Ivan Krejčí
    Synthesis and Analgesic Activity of Some Substituted 1-Benzofurans and 1-Benzothiophenes
    2000, Vol. 65, Issue 7, pp. 1093–1108 [Abstract]
  • Pavel Lhoták*, Václav Šťastný, Petra Zlatušková, Ivan Stibor, Veronika Michlová, Marcela Tkadlecová, Jaroslav Havlíček and Jan Sýkora
    Synthesis and 1H NMR Complexation Study of Thiacalix[4]arene Tetraacetates
    2000, Vol. 65, Issue 5, pp. 757–771 [Abstract]
  • Stanislav Rádl*, Petr Hezký, Jitka Urbánková, Petr Váchal and Ivan Krejčí
    Synthesis and Analgesic Activity of Some 1-Benzofurans, 1-Benzothiophenes and Indoles
    2000, Vol. 65, Issue 2, pp. 280–296 [Abstract]
  • Stanislav Rádl*, Wieland Hafner, Petr Hezký, Ivan Krejčí, Jan Proška and Josef Hájíček
    Synthesis and Antinociceptive Activity of Some 3-Chlorophenyl- and 6-Chloropyridin-2-yl Derivatives
    1999, Vol. 64, Issue 2, pp. 377–388 [Abstract]
  • Stanislav Rádl*, Wieland Hafner, Petr Hezký, Ivan Krejčí, Jan Proška and Jan Taimr
    Molecular Modification of Anpirtoline, a Non-Opioid Centrally Acting Analgesic
    1999, Vol. 64, Issue 2, pp. 363–376 [Abstract]
  • Karel Kefurt, Jaroslav Havlíček, Michaela Hamerníková, Zdeňka Kefurtová and Hana Votavová
    Conformation of 5-Amino-5-deoxypentonolactams
    1997, Vol. 62, Issue 12, pp. 1919–1930 [Abstract]
  • Stanislav Rádl
    Synthetic Studies Connected with the Preparation of 4-Cyclopropyl-7-fluoro-6-(4-methylpiperazin-1-yl)-1,2,4,9-tetrahydrothiazolo[5,4-b]quinoline-2,9-dione
    1997, Vol. 62, Issue 5, pp. 791–799 [Abstract]
  • Jaroslav Havlíček, Marcela Tkadlecová, Michaela Vyhnánková, Evgueni Pinkhassik and Ivan Stibor
    NMR Complexation Study of Several Oxyethylated Calix[4]arenes with Lithium, Sodium and Potassium Ions
    1996, Vol. 61, Issue 12, pp. 1783–1797 [Abstract]
  • Stanislav Rádl
    Preparation of 1-Hydroxyxanthen-9(9H)-ones and 1-Hydroxyacridin-9(10H)-ones via Corresponding 3,4-Dihydro-1,9(2H)-diones
    1995, Vol. 60, Issue 12, pp. 2127–2136 [Abstract]
  • Stanislav Rádl
    Synthesis of 3-Amino- and 3-Acylamino-1-cyclopropylquinolin-4(1H)-ones
    1994, Vol. 59, Issue 9, pp. 2123–2126 [Abstract]
  • Stanislav Rádl
    Synthesis of Ethyl 1-Ethyl-6-fluoro-1,4-dihydro-8-hydroxy-4-oxoquinoline-3-carboxylate
    1994, Vol. 59, Issue 9, pp. 2119–2122 [Abstract]
  • Jaroslav Havlíček, Karel Kefurt, Michal Hušák, Jiří Novotný and Bohumil Kratochvíl
    Structure of 2,3,4,5-Tetra-O-acetyl-6-amino-6-deoxy-D-galactonolactam
    1993, Vol. 58, Issue 7, pp. 1600–1606 [Abstract]
  • Jan Ondráček, Jaroslav Havlíček, Karel Kefurt, Jiří Jarý, Jiří Novotný and Bohumil Kratochvíl
    Structure of 2,3,4,5-Tetra-O-acetyl-6-amino-6-deoxy-D-allonolactam
    1992, Vol. 57, Issue 11, pp. 2367–2373 [Abstract]
  • Stanislav Rádl
    Preparation of Some Pyrazole Derivatives by Extrusion of Elemental Sulfur from 1,3,4-Thiadiazines
    1992, Vol. 57, Issue 3, pp. 656–659 [Abstract]
  • Stanislav Rádl, Jaroslav Moural and Radoslava Bendová
    Preparation of Some 2,3-Dihydro-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine Derivatives
    1992, Vol. 57, Issue 1, pp. 216–218 [Abstract]
  • Stanislav Rádl and Lenka Kovářová
    Preparation of Some Substituted 9,10-Dihydro-1-hydroxy-9-oxoacridine Derivatives
    1992, Vol. 57, Issue 1, pp. 212–215 [Abstract]
  • Stanislav Rádl and Magda Janichová
    Synthesis and Antibacterial Activity of Some 3-Hydroxyquinolones
    1992, Vol. 57, Issue 1, pp. 188–193 [Abstract]
  • Stanislav Rádl and Pavel Hradil
    Synthesis of some 1-alkyl-1,4-dihydro-4-oxo-1,7-naphthyridine-3-carboxylic acids
    1991, Vol. 56, Issue 11, pp. 2420–2429 [Abstract]
  • Stanislav Rádl and Lenka Kovářová
    Some reactions of N-propadienyl-4-quinolones
    1991, Vol. 56, Issue 11, pp. 2413–2419 [Abstract]
  • Stanislav Rádl and Lenka Kovářová
    Synthesis and antibacterial activity of new 7-substituted fluoroquinolones
    1991, Vol. 56, Issue 11, pp. 2406–2412 [Abstract]
  • Stanislav Rádl, Lenka Kovářová, Jaroslav Moural and Radoslava Bendová
    Structural modification and new methods for preparation of ofloxacin analogs
    1991, Vol. 56, Issue 9, pp. 1937–1943 [Abstract]
  • Stanislav Rádl, Lenka Kovářová and Jiří Holoubek
    Synthesis and antibacterial activity of some 1-(2-propynyl) and 1-propadienyl derivatives of 1,4-dihydro-4-oxoquinoline-3-carboxylic acids and similar heterocycles
    1991, Vol. 56, Issue 2, pp. 439–448 [Abstract]
  • Stanislav Rádl, Jaroslav Moural and Radoslava Bendová
    Synthesis and antibacterial activity of some 1-aryl-1,4-dihydro-4-oxocinnoline-3-carboxylic acids
    1990, Vol. 55, Issue 5, pp. 1311–1320 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Synthesis of some 1-aryl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids and their antibacterial activity
    1989, Vol. 54, Issue 8, pp. 2181–2189 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Synthesis and antimicrobial activity of some 3-oxo-3H-pyrido[3,2,1-kl]phenoxazine-2-carboxylic acids
    1989, Vol. 54, Issue 2, pp. 506–515 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Synthesis and biological activity of some basic-substituted 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinolines
    1988, Vol. 53, Issue 8, pp. 1812–1819 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity
    1987, Vol. 52, Issue 3, pp. 788–792 [Abstract]
  • Stanislav Rádl and Viktor Zikán
    Syntheses of some 4-dialkylaminoalkylamino derivatives of 2,3-dimethyl-2H- and 3,9-dimethyl-9H-pyrazolo[3,4-b]quinoline
    1986, Vol. 51, Issue 8, pp. 1692–1697 [Abstract]
  • Stanislav Rádl, Viktor Zikán and František Šmejkal
    Syntheses of some N-carboxymethyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H-(2H)-pyrazolo[3,4-b]quinoline with antiviral effects
    1985, Vol. 50, Issue 9, pp. 2010–2014 [Abstract]
  • Stanislav Rádl, Viktor Zikán and František Šmejkal
    Syntheses of 1, 2, and 9-methyl derivatives of 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity
    1985, Vol. 50, Issue 5, pp. 1057–1063 [Abstract]
  • Miloslav Ferles, Oldřich Kocián and Stanislav Rádl
    Reduction of some pyridine derivatives with zinc and formic acid
    1978, Vol. 43, Issue 6, pp. 1628–1633 [Abstract]