Collect. Czech. Chem. Commun. 2005, 70, 1357-1371
https://doi.org/10.1135/cccc20051357

The Antileukotrienic Derivatives and Homologues of [(Quinolin-2-ylmethoxy)sulfanyl]benzoic Acids with Reduced Lipophilicity

Miroslav Kuchařa,b,*, Bohumila Brunováa, Richard Junekb, Robert Rodlinga, Josef Hájíčeka, Vladimíra Panajotovác and Antonín Janderac

a Zentiva VUFB, Research Institute for Pharmacy and Biochemistry, 102 01 Prague 10, Czech Republic
b Research Centre LN00B125, Zentiva, a.s., 102 01 Prague 10, Czech Republic
c REaD-VUFB, Ltd., 180 66 Prague 9, Czech Republic

Individual author index pages


Other CCCC articles of these authors

  • Josef Hájíček
    Recent developments in syntheses of the post-secodine indole alkaloids. Part III: Rearranged alkaloid types
    2011, Vol. 76, Issue 12, pp. 2023–2083 [Abstract]
  • Josef Hájíček
    A Review on Recent Developments in Syntheses of the post-Secodine Indole Alkaloids. Part II: Modified Alkaloid Types
    2007, Vol. 72, Issue 7, pp. 821–898 [Abstract]
  • Václav Kozmík, Bedřich Košata, Jiří Svoboda* and Miroslav Kuchař
    A Study of 5-Nitroindole Alkylation
    2006, Vol. 71, Issue 5, pp. 679–690 [Abstract]
  • Miroslav Kuchař*, Vojtěch Kmoníček, Vladimíra Panajotová, Antonín Jandera, Bohumila Brunová, Richard Junek, Věra Bucharová, Jan Čejka and Dalibor Šatinský
    Derivatives of (Phenylsulfanyl)benzoic Acids with Multiple Antileukotrienic Activity
    2004, Vol. 69, Issue 11, pp. 2098–2120 [Abstract]
  • Josef Hájíček
    A Review on Recent Developments in Syntheses of the Post-Secodine Indole Alkaloids. Part I: The Primary Alkaloid Types
    2004, Vol. 69, Issue 9, pp. 1681–1767 [Abstract]
  • Vladimír Wsól*, Barbora Szotáková, Vendula Baliharová, Luděk Šišpera, Michal Holčapek, Lenka Kolářová, Bohumila Suchanová, Miroslav Kuchař and Lenka Skálová
    The Phase I Biotransformation of the Potential Antileukotrienic Drug Quinlukast in Rat Microsomes and Hepatocytes
    2004, Vol. 69, Issue 3, pp. 689–702 [Abstract]
  • Jiří Svoboda*, Michal Štádler, Antonín Jandera, Vladimíra Panajotová and Miroslav Kuchař
    Synthesis and Biological Evaluation of New Antiinflammatory 1-Benzothiophene-2-carboxanilides
    2000, Vol. 65, Issue 7, pp. 1082–1092 [Abstract]
  • Josef Hájíček* and Vladimír Hanuš
    On the Reaction of Deacetylvindoline with Thionyl Chloride
    2000, Vol. 65, Issue 5, pp. 789–796 [Abstract]
  • Stanislav Rádl*, Wieland Hafner, Petr Hezký, Ivan Krejčí, Jan Proška and Josef Hájíček
    Synthesis and Antinociceptive Activity of Some 3-Chlorophenyl- and 6-Chloropyridin-2-yl Derivatives
    1999, Vol. 64, Issue 2, pp. 377–388 [Abstract]
  • Miroslav Kuchař, Kateřina Čulíková, Vladimíra Panajotovová, Bohumila Brunová, Antonín Jandera and Vojtěch Kmoníček
    2,4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism
    1998, Vol. 63, Issue 1, pp. 103–114 [Abstract]
  • Miroslav Kuchař, Marie Poppová, Antonín Jandera, Vladimíra Panajotovová, Hana Zůnová, Miloš Buděšínský, Hana Tomková, Alexandr Jegorov and Jan Taimr
    Chiral Forms of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid (Flobufen) and Its Metabolite.Synthesis and Basic Biological Properties
    1997, Vol. 62, Issue 3, pp. 498–509 [Abstract]
  • Miroslav Kuchař, Václav Vosátka, Marie Poppová, Eva Knězová, Vladimíra Panajotovová, Hana Tomková and Jan Taimr
    Some Analogs of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid: Synthesis and Antiinflammatory Activity
    1995, Vol. 60, Issue 6, pp. 1026–1033 [Abstract]
  • Miroslav Kuchař, Marie Poppová, Hana Zůnová, Eva Knězová, Václav Vosátka and Marek Příhoda
    4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid and Its Derivatives
    1994, Vol. 59, Issue 12, pp. 2705–2713 [Abstract]
  • Ludmila Fišnerová, Bohumila Brunová, Zuzana Kocfeldová, Jana Tíkalová, Eva Maturová and Jaroslava Grimová
    Synthesis and analgetic efficiency of some oxy and oxo derivatives of 4(3H)-quinazolinone
    1991, Vol. 56, Issue 11, pp. 2373–2381 [Abstract]
  • Bohdan Schneider, Václav Rejholec and Miroslav Kuchař
    Three-dimensional structures of substituted diphenyl sulfides
    1990, Vol. 55, Issue 11, pp. 2590–2601 [Abstract]
  • Miloš Beran, Antonín Černý, Miroslav Kuchař, Hana Adamírová, Jiří Holubek, Jan Taimr, Jaroslav Vachek, Maria Frühaufová, Karel Řežábek, Martin Valchář and Ivan Krejčí
    9,10-Dihydroergopeptines modified in position 6
    1990, Vol. 55, Issue 3, pp. 819–832 [Abstract]
  • Miroslav Kuchař, Jaroslava Grimová, Václav Rejholec, Hana Tomková, Magda Jelínková and Jiří Holubek
    Use of QSAR in design of antiinflammatory fluorinated arylalkanoic acids
    1990, Vol. 55, Issue 1, pp. 296–306 [Abstract]
  • František Tureček, Libor Brabec, Tomáš Vondrák, Vladimír Hanuš, Josef Hájíček and Zdeněk Havlas
    Sulfenic acids in the gas phase. Preparation, ionization energies and heats of formation of methane-, ethene-, and benzenesulfenic acid
    1988, Vol. 53, Issue 9, pp. 2140–2158 [Abstract]
  • Miroslav Kuchař, Eva Maturová, Bohumila Brunová, Jaroslava Grimová, Hana Tomková and Jiří Holubek
    Quantitative relations between structure and antiinflammatory activity of aryloxoalkanoic acids
    1988, Vol. 53, Issue 8, pp. 1862–1872 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Jaroslava Grimová, Stanislav Vaněček and Jiří Holubek
    Synthesis of cyclohexylaliphatic acids and their pharmacological properties
    1986, Vol. 51, Issue 12, pp. 2896–2908 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Jaroslava Grimová, Václav Rejholec and Václav Čepelák
    On the quantitative relations between structure and antiaggregation activity of ω-aryl-ω-oxoalkanoic acids
    1986, Vol. 51, Issue 11, pp. 2617–2625 [Abstract]
  • Josef Hájíček and Jan Trojánek
    (-)-Strempeliopine, stereoselective total synthesis and the determination of absolute configuration
    1986, Vol. 51, Issue 8, pp. 1731–1742 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Václav Rejholc, Magda Jelínková, Jiří Holubek and Oldřich Němeček
    Quantitative relations between structure and activation of fibrinolysis in selected series of arylaliphatic acids
    1984, Vol. 49, Issue 1, pp. 122–136 [Abstract]
  • Miroslav Kuchař, Václav Rejholec, Zdeněk Roubal and Oluše Matoušová
    The effects of lipophilicity on the inhibition of denaturation of serum albumin and on the activation of fibrinolysis observed with a series of benzyloxyarylaliphatic acids
    1983, Vol. 48, Issue 4, pp. 1077–1088 [Abstract]
  • Josef Hájíček and Jan Trojánek
    Synthesis of optically active 4,4- and 5,5-disubstituted 4,5-dihydro-6H-canthin-6-ones and their CD spectra
    1982, Vol. 47, Issue 12, pp. 3306–3311 [Abstract]
  • Josef Hájíček, Jiří Holubek and Jan Trojánek
    Synthesis of 4,4- and 5,5-disubstituted 4,5-dihydro-6H-canthin-6-ones
    1982, Vol. 47, Issue 10, pp. 2749–2762 [Abstract]
  • Miroslav Kuchař, Václav Rejholec, Bohumila Brunová, Jaroslava Grimová, Oluše Matoušová, Oldřich Němeček and Hana Čepeláková
    Benzyloxyarylaliphatic acids: Synthesis and quantitative relations between structure and antiinflammatory activity
    1982, Vol. 47, Issue 9, pp. 2514–2524 [Abstract]
  • Josef Hájíček and Jan Trojánek
    Stereospecific total synthesis of (+)-18-methylenevincadifformine
    1982, Vol. 47, Issue 9, pp. 2448–2453 [Abstract]
  • Josef Hájíček and Jan Trojánek
    Absolute configuration of (R)-(-)-2-allyl-2-ethyl-3-methoxycarbonylpropionic acid
    1982, Vol. 47, Issue 3, pp. 809–813 [Abstract]
  • Josef Hájíček and Jan Trojánek
    Synthesis of 2-allyl-2-ethylsuccinic anhydride
    1981, Vol. 46, Issue 5, pp. 1262–1271 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Václav Rejholec, Zdeněk Roubal and Oldřich Němeček
    The synthesis of arylpropionic acids and the quantitative relationship between the structure and the activation of fibrinolysis
    1981, Vol. 46, Issue 5, pp. 1173–1187 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Zdeněk Roubal, Jiří Schlanger and Oldřich Němeček
    Synthesis of arylacetic acids and their effect on activation of fibrinolysis. Quantitative relations between structure and biological activity
    1980, Vol. 45, Issue 5, pp. 1401–1409 [Abstract]
  • Miroslav Kuchař, Václav Rejholec, Zdeněk Roubal and Oldřich Němeček
    Quantitative relationships between structure and fibrinolytic activity in the series of α-methyl-β-arylpropionic acids
    1979, Vol. 44, Issue 1, pp. 183–193 [Abstract]