Collect. Czech. Chem. Commun. 1983, 48, 1077-1088

The effects of lipophilicity on the inhibition of denaturation of serum albumin and on the activation of fibrinolysis observed with a series of benzyloxyarylaliphatic acids

Miroslav Kuchař, Václav Rejholec, Zdeněk Roubal and Oluše Matoušová

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Activation of fibrinolysis and inhibition of denaturation of serum albumin by a series of substituted benzyloxyarylaliphatic acids have been measured and analyzed in relation to the physico-chemical parameters of these acids. The lipophilicity of the benzyloxy derivatives was characterized both by the tabulated parameters π and by experimental data obtained by TLC. Regression analysis has revealed that the derivatives manifest higher lipophilicities in both the activation of fibrinolysis and the inhibition of denaturation, and that these lipophilicities are better described by the tabulated data than by experimental values. Taking into account the earlier results of regression analysis of erythrocyte membrane stabilization and antiinflammatory activity it can be judged that the role of lipophilicities of these substances is influenced by the nature of their interaction with the biological system.