Collection Symposium Series 2005, 7, 291-295
https://doi.org/10.1135/css200507291
Published online 2015-11-08 11:54:12

Pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives: Their syntheses and utilization as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma

Karel Pomeisl, Ivan Votruba, Antonín Ho and Radek Pohl

Individual author index pages


Other CCCC articles of these authors

  • Petr Kočalka, Markéta Rinnová, Václav Vaněk, Dominik Rejman, Ivan Votruba, Ivana Tomečková, Šárka Králíková, Magdalena Petrová, Ondřej Páv, Radek Pohl, Miloš Buděšínský, Radek Liboska, Zdeněk Točík and Ivan Rosenberg
    Novel nucleoside phosphonic acids-based inhibitors of thymidine phosphorylase
    Symposium Series 2005, Vol. 7, pp. 415–416 [Abstract]
    Published online 2015-11-08 11:56:57
  • Kateřina Hořejší, Radek Pohl and Antonín Holý
    Tricyclic etheno analogs of purines derived from 2-amino-6-chloropurine
    Symposium Series 2005, Vol. 7, pp. 403–404 [Abstract]
    Published online 2015-11-08 11:56:30
  • Peter Šilhár, Radek Pohl, Ivan Votruba and Michal Hocek
    Synthesis and transformations of 6-(hydroxymethyl)purines
    Symposium Series 2005, Vol. 7, pp. 221–224 [Abstract]
    Published online 2015-11-08 11:52:45
  • Radek Pohl, Dominik Rejman, Petr Kočalka and Ivan Rosenberg
    Pyrrolidine nucleotide analogues – conformation study
    Symposium Series 2005, Vol. 7, pp. 165–166 [Abstract]
    Published online 2015-11-08 11:51:48
  • Dominik Rejman, Petr Kočalka, Radek Pohl and Ivan Rosenberg
    Synthesis of 4'-N pyrrolidine nucleosides, nucleotides, and oligonucleotides
    Symposium Series 2005, Vol. 7, pp. 159–163 [Abstract]
    Published online 2015-11-08 11:51:43
  • Ivan Rosenberg, Ivan Barvik, Miloš Buděšínský, Petr Kočalka, Šárka Králíková, Radek Liboska, Ondřej Pačes, Ondřej Páv, Magdalena Petrová, Radek Pohl, Martina Pressová, Dominik Rejman, Ivan Votruba and Zdeněk Točík
    Nucleoside phosphonic acids and related oligonucleotides: Structural diversity vs biological properties
    Symposium Series 2005, Vol. 7, pp. 153–157 [Abstract]
    Published online 2015-11-08 11:51:38
  • Ondřej Sedláček, Radek Pohl and Antonín Holý
    Synthesis of 8-C-substituted 2,6-diaminopurine acyclic nucleoside phosphonates by Negishi cross-coupling
    Symposium Series 2008, Vol. 10, pp. 449–450 [Abstract]
    Published online 2015-10-30 18:44:50
  • Radek Pohl, Miloš Buděšínský, Dominik Rejman, Petr Kočalka and Ivan Rosenberg
    Conformation of pyrrolidine ring in pyrrolidine nucleotide analogues
    Symposium Series 2008, Vol. 10, pp. 435–436 [Abstract]
    Published online 2015-10-30 18:44:27
  • Karel Pomeisl, Antonín Holý, Ivan Votruba, Radim Nencka and Radek Pohl
    Facile syntheses of pyrimidine acyclic nucleoside phosphonates and their potential evaluation for biomedical applications
    Symposium Series 2008, Vol. 10, pp. 201–205 [Abstract]
    Published online 2015-10-30 18:37:39
  • Dominik Rejman and Radek Pohl
    Synthesis of PME derivatives of nucleobases with conformation locked via pyrrolidine ring
    Symposium Series 2011, Vol. 12, pp. 446–447 [Abstract]
    Published online 2015-08-20 10:23:57
  • Karel Pomeisl, Antonín Holý and Marcela Krečmerová
    Use of 1,3-dioxolanes in the syntheses of α-branched alkyl and aryl N-9-[2-(phosphonomethoxy)ethyl]purines
    Symposium Series 2011, Vol. 12, pp. 438–440 [Abstract]
    Published online 2015-08-20 10:23:40
  • Marcela Krečmerová, Tomáš Tichý, Jiří Blažek and Karel Pomeisl
    New strategies in synthesis of acyclic nucleoside phosphonate prodrugs
    Symposium Series 2011, Vol. 12, pp. 163–166 [Abstract]
    Published online 2015-08-20 10:00:06
  • Lenka Poštová Slavětínská, Radek Pohl and Dominik Rejman
    Conformation analysis of nucleoside analogues containing selenium and tellurium in five-membered pseudosugar ring
    Symposium Series 2014, Vol. 14, pp. 354–355 [Abstract]
    Published online 2015-07-06 23:08:08
  • Radek Pohl, Lenka Poštová Slavětínská and Dominik Rejman
    Pyrrolidine nucleotides conformationally constrained via hydrogen bonding
    Symposium Series 2014, Vol. 14, pp. 352–353 [Abstract]
    Published online 2015-07-06 23:08:03
  • Jitka Daďová, Petr Orság, Radek Pohl, Marie Brázdová, Miroslav Fojta and Michal Hocek
    Study of DNA-protein interactions by cross-link formation using aqueous Michael addition
    Symposium Series 2014, Vol. 14, pp. 240–241 [Abstract]
    Published online 2015-07-06 23:03:09
  • Tomáš Tichý, Karel Pomeisl, Marcela Krečmerová and Charles E. McKenna
    Tyrosine-based prodrugs of acyclic nucleoside phosphonates
    Symposium Series 2014, Vol. 14, pp. 126–128 [Abstract]
    Published online 2015-07-06 22:58:53
  • Petr Nauš, Pavla Perlíková, Radek Pohl and Michal Hocek*
    Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2′-C-methylribonucleosides, arabinonucleosides and 2′-deoxy-2′-fluoroarabinonucleosides
    2011, Vol. 76, Issue 8, pp. 957–988 [Abstract]
  • Zbyněk Hasník, Radek Pohl, Blanka Klepetářová and Michal Hocek*
    Synthesis of (purin-6-yl)acetates and their transformations to 6-(2-hydroxyethyl)- and 6-(carbamoylmethyl)purines
    2009, Vol. 74, Issue 7-8, pp. 1035–1059 [Abstract] [Full text pdf]
  • Louis Adriaenssens, Lukáš Severa, Jan Vávra, Tereza Šálová, Jakub Hývl, Martina Čížková, Radek Pohl, David Šaman and Filip Teplý*
    Bio- and air-tolerant carbon–carbon bond formations via organometallic ruthenium catalysis
    2009, Vol. 74, Issue 7-8, pp. 1023–1034 [Abstract] [Full text pdf]
  • Dominik Rejman*, Petr Kočalka, Radek Pohl, Zdeněk Točík and Ivan Rosenberg*
    Synthesis and hybridization of oligonucleotides modified at AMP sites with adenine pyrrolidine phosphonate nucleotides
    2009, Vol. 74, Issue 6, pp. 935–955 [Abstract]
  • Michal Hocek*, Peter Šilhár and Radek Pohl
    Cytostatic and Antiviral 6-Arylpurine Ribonucleosides VIII. Synthesis and Evaluation of 6-Substituted Purine 3'-Deoxyribonucleosides
    2006, Vol. 71, Issue 10, pp. 1484–1496 [Abstract]
  • Peter Šilhár, Radek Pohl, Ivan Votruba, Blanka Klepetářová and Michal Hocek*
    Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl-2-(hydroxymethyl)purine Bases and Nucleosides
    2006, Vol. 71, Issue 6, pp. 788–803 [Abstract]
  • Karel Pomeisl*, Ivan Votruba, Antonín Holý and Radek Pohl
    Syntheses of Base and Side-Chain Modified Pyrimidine 1-[2-(Phosphonomethoxy)propyl] Derivatives as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-Lymphoma
    2006, Vol. 71, Issue 4, pp. 595–624 [Abstract]
  • Silvie Vrbovská*, Antonín Holý, Radek Pohl and Milena Masojídková
    Bifunctional Acyclic Nucleoside Phosphonates. 1. Symmetrical 1,3-Bis[(phosphonomethoxy)propan-2-yl] Derivatives of Purines and Pyrimidines
    2006, Vol. 71, Issue 4, pp. 543–566 [Abstract]
  • Kateřina Hořejší, Radek Pohl and Antonín Holý*
    Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts
    2006, Vol. 71, Issue 1, pp. 77–90 [Abstract]
  • Peter Šilhár, Radek Pohl, Ivan Votruba and Michal Hocek*
    Synthesis of 2-Substituted 6-(Hydroxymethyl)purine Bases and Nucleosides
    2005, Vol. 70, Issue 10, pp. 1669–1695 [Abstract]
  • Karel Pomeisl*, Radek Pohl, Antonín Holý and Ivan Votruba
    Simple Transformation of Thymine 1-[3-Hydroxy-2-(phosphonomethoxy)propyl] Derivatives to Their 1-[3-Fluoro-2-(phosphonomethoxy)propyl] Counterparts
    2005, Vol. 70, Issue 9, pp. 1465–1481 [Abstract]
  • Radek Pohl, Jan Sýkora, Petr Maloň, Stanislav Böhm*, Bohumil Kratochvíl and Josef Kuthan
    Sterically Crowded Heterocycles. XIII. An Insight Into the Absolute Stereochemistry of Atropisomeric (Z)-3-(Imidazo[1,2-a]pyridin-3-yl)prop-2-en-1-ones
    2000, Vol. 65, Issue 10, pp. 1643–1652 [Abstract]
  • Robert Klvaňa, Radek Pohl, Jan Pawlas, Jan Čejka, Hana Dvořáková, Richard Hrabal, Stanislav Böhm*, Bohumil Kratochvíl and Josef Kuthan
    Sterically Crowded Heterocycles. XII. Atropisomerism of (1-Aryl-3,5-diphenyl-1H-pyrrol-2-yl)(phenyl)methanones
    2000, Vol. 65, Issue 5, pp. 651–666 [Abstract]
  • Stanislav Böhm*, Radek Pohl and Josef Kuthan
    Sterically Crowded Heterocycles. XI. A Semiempirical Prediction of Enantiomerization Barriers for Substituted (Z)-3-(Imidazo[1,2-a]pyridin-3-yl)-1-phenylprop-2-en-1-ones
    1999, Vol. 64, Issue 11, pp. 1761–1769 [Abstract]
  • Radek Pohl, Stanislav Böhm and Josef Kuthan*
    Sterically Crowded Heterocycles. X. A New Mechanistic Approach to the Ferricyanide Oxidation of 4,6'-Disubstituted 1-(Pyridin-2'-yl)-2,6-diphenylpyridinium Salts
    1999, Vol. 64, Issue 8, pp. 1274–1294 [Abstract]
  • Radek Pohl, Viktor Prutianov and Svatava Smrčková-Voltrová
    Nucleophilic Substitution in a Series of 4-Nitronicotinic Acid 1-Oxide Derivatives
    1995, Vol. 60, Issue 7, pp. 1170–1177 [Abstract]