Collection Symposium Series 2008, 10, 487-490
https://doi.org/10.1135/css200810487
Published online 2015-10-30 18:46:12

Phosphorothioate analogues of m7GTP: Strong inhibitors of translation with increased resistance towards enzymatic degradation

Joanna Kowalska, Marcin Ziemniak, Maciej Lukaszewicz, Joanna Zuberek, Malwina Strenkowska, Edward Darżynkiewicz and Jacek Jemielity

Individual author index pages


Other CCCC articles of these authors

  • Anna Niedzwiecka-Kornas, Lidia Chlebicka, Janusz Stępiński, Marzena Jankowska-Anyszka, Zbigniew Wieczorek, Edward Darżynkiewicz, Robert E. Rhoads and Ryszard Stolarski
    Spectroscopic studies on association of mRNA cap-analogues with human translation factor eIF4E. From modelling of interactions to inhibitory properties
    Symposium Series 1999, Vol. 2, pp. 214–218 [Abstract]
    Published online 2016-05-08 23:30:18
  • Joanna Zuberek, Janusz Stępiński, Anna Niedzwiecka, Ryszard Stolarski, Harri Salo, Harri Lönnberg and Edward Darżynkiewicz
    Synthesis of tetraribonucleotide cap analogue m7GpppAm2'pUm2'pAm2' and its interaction with eukaryotic initiation factor eIF4E
    Symposium Series 2002, Vol. 5, pp. 399–403 [Abstract]
    Published online 2016-01-25 20:52:22
  • Jacek Jemielity, Joanna Zuberek, Janusz Stępiński, Magdalena Lewdorowicz, Anna Niedzwiecka, Dorota Haber, Fowler Tolvert, Ryszard Stolarski, Robert E. Rhoads and Edward Darżynkiewicz
    Synthesis, physico-chemical and biochemical properties of the novel tri-, tetra- and pentaphosphate mRNA cap analogues
    Symposium Series 2002, Vol. 5, pp. 159–168 [Abstract]
    Published online 2016-01-25 20:39:45
  • Janusz Stępiński, Jacek Jemielity, Magdalena Lewdorowicz, Marzena Jankowska-Anyszka and Edward Darżynkiewicz
    Catalytic efficiency of divalent metal salts in dinucleoside 5',5'-triphosphate bond formation
    Symposium Series 2002, Vol. 5, pp. 154–158 [Abstract]
    Published online 2016-01-25 20:39:38
  • Janusz Stępiński, Remigiusz Worch, Joanna Zuberek, Elzbieta Bojarska, Jacek Jemielity, Magdalena Lewdorowicz, Ryszard Stolarski, Dorota Haber and Edward Darżynkiewicz
    Synthesis and preliminary characterization of mRNA 5' cap analogues containing ribavirin
    Symposium Series 2005, Vol. 7, pp. 479–480 [Abstract]
    Published online 2015-11-08 11:58:43
  • Magdalena Lewdorowicz, Jacek Jemielity, Ryszard Kierzek, Michal Shapira, Janusz Stępiński, Ryszard Stolarski and Edward Darżynkiewicz
    Solid-supported synthesis of 5' mRNA cap-4 from trypanosomatides
    Symposium Series 2005, Vol. 7, pp. 433–435 [Abstract]
    Published online 2015-11-08 11:57:26
  • Joanna Kowalska, Magdalena Lewdorowicz, Joanna Zuberek, Elzbieta Bojarska, Zbigniew M. Darzynkiewicz, Ewa Grudzien, Richard E. Davis, Robert E. Rhoads, Janusz Stępiński, Ryszard Stolarski, Edward Darżynkiewicz and Jacek Jemielity
    Synthesis and properties of phosphorothioate 5' mRNA cap dinucleotides
    Symposium Series 2005, Vol. 7, pp. 417–419 [Abstract]
    Published online 2015-11-08 11:57:01
  • Jacek Jemielity, Janusz Stępiński, Joanna Zuberek, Ewa Grudzien, Magdalena Lewdorowicz, Ryszard Stolarski, Robert E. Rhoads and Edward Darżynkiewicz
    Dinucleotide analogues of the mRNA cap that enhance translational efficiency
    Symposium Series 2005, Vol. 7, pp. 361–365 [Abstract]
    Published online 2015-11-08 11:55:26
  • Marcin Kalek, Jacek Jemielity, Ewa Grudzien, Joanna Zuberek, Zbigniew M. Darzynkiewicz, Elzbieta Bojarska, Janusz Stępiński, Ryszard Stolarski, Richard E. Davis, Robert E. Rhoads and Edward Darżynkiewicz
    Synthesis and biochemical properties of the novel, enzymatically stable mRNA cap analogues with versatile potential applications
    Symposium Series 2005, Vol. 7, pp. 355–359 [Abstract]
    Published online 2015-11-08 11:55:20
  • Sylwia A. Szczepaniak, Jacek Jemielity, Joanna Zuberek, Joanna Kufel and Edward Darżynkiewicz
    Synthesis of nonhydrolyzable cap analog substituted sepharose for affinity purification of decaping enzymes
    Symposium Series 2008, Vol. 10, pp. 461–464 [Abstract]
    Published online 2015-10-30 18:45:14
  • Anna Wypijewska, Elzbieta Bojarska, Janusz Stępiński, Marzena Jankowska-Anyszka, Richard Davis and Edward Darżynkiewicz
    Novel ribose modified dinucleotide cap analogue: Synthesis and hydrolytic susceptibility to scavenger decapping enzyme
    Symposium Series 2008, Vol. 10, pp. 457–460 [Abstract]
    Published online 2015-10-30 18:45:10
  • Anna Rydzik, Joanna Zuberek, Joanna Kowalska, Edward Darżynkiewicz and Jacek Jemielity
    Bisphosphonate modification in tetraphosphate 5'mRNA cap analogs – synthesis and biochemical properties
    Symposium Series 2008, Vol. 10, pp. 444–448 [Abstract]
    Published online 2015-10-30 18:44:45
  • Marta Kulis, Joanna Kowalska, Joanna Zuberek, Edward Darżynkiewicz and Jacek Jemielity
    Imidodiphospate modification of dinucleotide mRNA cap analogs
    Symposium Series 2008, Vol. 10, pp. 389–392 [Abstract]
    Published online 2015-10-30 18:43:04
  • Joanna Kowalska, Joanna Zuberek, Zbigniew M. Darzynkiewicz, Maciej Lukaszewicz, Edward Darżynkiewicz and Jacek Jemielity
    Synthesis and properties of boranophosphate mRNA cap analogues
    Symposium Series 2008, Vol. 10, pp. 383–385 [Abstract]
    Published online 2015-10-30 18:42:53
  • Joanna Kowalska, Ewa Grudzien-Nogalska, Magdalena Lewdorowicz, Joanna Zuberek, Elzbieta Bojarska, Janusz Stępiński, Robert E. Rhoads, Edward Darżynkiewicz, Richard E. Davis and Jacek Jemielity
    Phosphorothioate analogues of mRNA cap with superior biological properties
    Symposium Series 2008, Vol. 10, pp. 362–365 [Abstract]
    Published online 2015-10-30 18:42:08
  • Marcin Warminski, Joanna Kowalska, Monika Nowakowska, Joanna Zuberek, Maciej Lukaszewicz, Edward Darżynkiewicz and Jacek Jemielity
    Synthesis and properties of new thio-substituted mRNA cap analogs
    Symposium Series 2011, Vol. 12, pp. 378–380 [Abstract]
    Published online 2015-08-20 10:19:40
  • Joanna Kowalska, Malwina Strenkowska, Przemysław Wanat and Jacek Jemielity
    Cyanoethyl derivatives of phosphate and thiophosphate – new reagents for efficient synthesis of phosphate modified nucleotides
    Symposium Series 2011, Vol. 12, pp. 375–377 [Abstract]
    Published online 2015-08-20 10:19:34
  • Pawel Dabrowski-Tumanski, Joanna Kowalska, Agnieszka Osowniak and Jacek Jemielity
    Synthesis of nucleotide sugars and nucleoside 5'-phosphosulfates by MgCl2 mediated coupling
    Symposium Series 2011, Vol. 12, pp. 354–356 [Abstract]
    Published online 2015-08-20 10:18:50
  • Jacek Jemielity, Maciej Lukaszewicz, Joanna Kowalska, Jakub Czarnecki, Joanna Zuberek and Edward Darżynkiewicz
    Synthesis and properties of dinucleotide cap analog for mRNA 5' end labeling
    Symposium Series 2011, Vol. 12, pp. 351–353 [Abstract]
    Published online 2015-08-20 10:18:44
  • Marcin Ziemniak, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Edward Darżynkiewicz and Jacek Jemielity
    Dinucleotide cap analogs bearing bridging and non-bridging modifications within tetraphosphate chain
    Symposium Series 2011, Vol. 12, pp. 500–502 [Abstract]
    Published online 2015-08-20 09:57:25
  • Malgorzata Zytek, Joanna Kowalska, Edward Darżynkiewicz and Jacek Jemielity
    The first examples of phosphate modified trimethylguanosine cap analogues
    Symposium Series 2011, Vol. 12, pp. 503–505 [Abstract]
    Published online 2015-08-20 09:57:13
  • Malgorzata Zytek, Joanna Kowalska, Maciej Lukaszewicz, Edward Darżynkiewicz, Anna Niedzwiecka and Jacek Jemielity
    Evaluation of biological activity of trimethylguanosine cap analogs modified within the 5’,5’-triphosphate bridge
    Symposium Series 2014, Vol. 14, pp. 416–417 [Abstract]
    Published online 2015-07-06 23:10:41
  • Blazej A. Wojtczak, Joanna Kowalska, Malgorzata Honcharenko, Roger Strömberg, C. I. Edward Smith, Edward Darżynkiewicz and Jacek Jemielity
    "Clickable" TMG-cap analogs modified within the triphosphate bridge and their incorporation into oligonucleotides using click chemistry
    Symposium Series 2014, Vol. 14, pp. 406–407 [Abstract]
    Published online 2015-07-06 23:10:13
  • Marcin Warminski, Zofia Tomasiewicz, Krystian Ubych, Joanna Kowalska and Jacek Jemielity
    Synthesis of amino- or carboxy-functionalized mRNA cap analogs for fluorescence labeling and conjugation with macromolecules
    Symposium Series 2014, Vol. 14, pp. 403–405 [Abstract]
    Published online 2015-07-06 23:10:08
  • Zofia Tomasiewicz, Marcin Warminski, Krystian Ubych, Maciej Lukaszewicz, Joanna Zuberek, Anna Kropiwnicka, Edward Darżynkiewicz, Joanna Kowalska and Jacek Jemielity
    Properties and applications of amino- or carboxyfunctionalized mRNA 5’-cap analogues and their conjugates
    Symposium Series 2014, Vol. 14, pp. 387–388 [Abstract]
    Published online 2015-07-06 23:09:29
  • Sylwia Walczak, Przemysław Wanat, Anna Nowicka, Joanna Zuberek, Joanna Kowalska and Jacek Jemielity
    Synthesis and properties of dinucleotide cap analogs containing a triazole ring within the oligophosphate bridge
    Symposium Series 2014, Vol. 14, pp. 289–290 [Abstract]
    Published online 2015-07-06 23:05:19
  • Maciej Majewski, Malwina Strenkowska, Joanna Zuberek, Joanna Kowalska and Jacek Jemielity
    Synthesis and properties of cap-decorated gold nanoparticles
    Symposium Series 2014, Vol. 14, pp. 287–288 [Abstract]
    Published online 2015-07-06 23:05:13
  • Joanna Kowalska, Marek R. Baranowski, Anna Nowicka, Renata Kasprzyk, Joanna Zuberek, Jacek Wojcik and Jacek Jemielity
    Synthesis and properties of nucleotides containing a fluorophosphate moiety
    Symposium Series 2014, Vol. 14, pp. 159–162 [Abstract]
    Published online 2015-07-06 23:00:21
  • Marcin Ziemniak, Jeff Mugridge, Joanna Kowalska, Agnieszka Stelmachowska, Joanna Zuberek, Edward Darżynkiewicz, John D. Gross, Robert E. Rhoads and Jacek Jemielity
    Utility of chemically modified cap analogues in studying Dcp1/2 decapping complex mechanism of action
    Symposium Series 2014, Vol. 14, pp. 155–158 [Abstract]
    Published online 2015-07-06 23:00:15
  • Alicja Stachelska*, Zbigniew J. Wieczorek, Janusz Stępiński, Marzena Jankowska-Anyszka, Harri Lönnberg and Edward Darżynkiewicz
    Kinetics of the Imidazolium Ring-Opening of mRNA 5'-cap Analogs in Aqueous Alkali
    2006, Vol. 71, Issue 4, pp. 567–578 [Abstract]
  • Ryszard Stolarski, Konrad Zdanowski, Lidia Chlebicka, Zbigniew Wieczorek, Arkadiusz Sitek, Janusz Stępiński, Marzena Jankowska, Jorma Mattinen, Andrzej Temeriusz and Edward Darżynkiewicz
    Inter- and intramolecular stacking of mRNA cap-analogues – relevance to initiation of translation
    1996, Vol. 61, Special Issue, pp. S217–S221 [Abstract]
  • Marzena Jankowska, Janusz Stępiński, Ryszard Stolarski, Zbigniew Wieczorek, Andrzej Temeriusz, Dorota Haber and Edward Darżynkiewicz
    1H NMR and fluorescence studies of new mRNA 5'-cap analogues
    1996, Vol. 61, Special Issue, pp. S197–S202 [Abstract]
  • Elzbieta Bojarska, Janusz Stępiński, Andrzej Guranowski, Elzbieta Starzynska, Lidia Chlebicka, Marzena Jankowska and Edward Darżynkiewicz
    Hydrolytic susceptibilities of modified 5'-mRNA cap analogues to the yellow lupin Ap3A and Ap4A hydrolases
    1996, Vol. 61, Special Issue, pp. S192–S196 [Abstract]
  • Marzena Jankowska, Janusz Stępiński, Ryszard Stolarski, Andrzej Temeriusz and Edward Darżynkiewicz
    Synthesis and properties of new NH2 and N7 substituted GMP and GTP 5'-mRNA cap analogues
    1993, Vol. 58, Special Issue, pp. S138–S141 [Abstract]
  • Marzena Jankowska, Andrzej Temeriusz, Ryszard Stolarski and Edward Darżynkiewicz
    Synthesis of m22,7GTP- and m32,2,7GTP-Sepharose 4B: New affinity resins for isolation of cap binding proteins
    1993, Vol. 58, Special Issue, pp. S132–S137 [Abstract]
  • Janusz Stępiński, Lidia Grabowska, Edward Darżynkiewicz, Andrzej Temeriusz, Ryszard Stolarski, Stanley M. Tahara, David Shugar, Pia Järvinen and Harri Lönnberg
    Synthesis, conformation and hydrolytic stability of modified mRNA 5'-cap structures: P1,P3-dinucleoside triphosphates derived from guanosine and acyclic analogues of 7-methyl-, N2,7-dimethyl- and N2,N2,7-trimethylguanosines
    1990, Vol. 55, Special Issue, pp. S117–S120 [Abstract]
  • Zbigniew Wieczorek, Edward Darżynkiewicz, Janusz Stępiński and Harri Lönnberg
    Fluorescence studies on P1,P3-dinucleoside triphosphates related to mRNA cap: Acidity and intramolecular stacking
    1990, Vol. 55, Issue 11, pp. 2765–2768 [Abstract]