Collect. Czech. Chem. Commun. 2007, 72, 1219-1228
https://doi.org/10.1135/cccc20071219

5-Cinnamoyl- and 5-(Ethoxycarbonyl)-6-styryl Derivatives of 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones

Maksim A. Kolosova,*, Valeriy D. Orlova, Valeriy V. Vashchenkob, Svetlana V. Shishkinab and Oleg V. Shishkinb

a Department of Organic Chemistry, V. N. Karazin Kharkiv National University, Svobody sq. 4, 61077 Kharkiv, Ukraine
b State Scientific Institution "Institute for Single Crystals", National Academy of Sciences of Ukraine, Lenin Ave. 60, 61001 Kharkiv, Ukraine

Abstract

Several 5-cinnamoyl- and 5-(ethoxycarbonyl)-6-styryl derivatives of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones were obtained and their physicochemical properties were investigated. The introduction of alkyl substituent in position 1 of dihydropyrimidine ring was shown to promote the Claisen-Schmidt reaction on acetyl group only; without the alkyl both acetyl and 6-methyl groups participate in the reaction.

Keywords: 5-Acetyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones; Pyrimidines; Benzaldehydes; Chalcones; Claisen-Schmidt reactions; Cinnamoyl derivatives.

References: 11 live references.