Collect. Czech. Chem. Commun. 1998, 63, 103-114
https://doi.org/10.1135/cccc19980103

2,4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism

Miroslav Kuchař, Kateřina Čulíková, Vladimíra Panajotovová, Bohumila Brunová, Antonín Jandera and Vojtěch Kmoníček

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3, Czech Republic

Individual author index pages


Other CCCC articles of these authors

  • Václav Kozmík, Bedřich Košata, Jiří Svoboda* and Miroslav Kuchař
    A Study of 5-Nitroindole Alkylation
    2006, Vol. 71, Issue 5, pp. 679–690 [Abstract]
  • Miroslav Kuchař*, Bohumila Brunová, Richard Junek, Robert Rodling, Josef Hájíček, Vladimíra Panajotová and Antonín Jandera
    The Antileukotrienic Derivatives and Homologues of [(Quinolin-2-ylmethoxy)sulfanyl]benzoic Acids with Reduced Lipophilicity
    2005, Vol. 70, Issue 9, pp. 1357–1371 [Abstract]
  • Miroslav Kuchař*, Vojtěch Kmoníček, Vladimíra Panajotová, Antonín Jandera, Bohumila Brunová, Richard Junek, Věra Bucharová, Jan Čejka and Dalibor Šatinský
    Derivatives of (Phenylsulfanyl)benzoic Acids with Multiple Antileukotrienic Activity
    2004, Vol. 69, Issue 11, pp. 2098–2120 [Abstract]
  • Vladimír Wsól*, Barbora Szotáková, Vendula Baliharová, Luděk Šišpera, Michal Holčapek, Lenka Kolářová, Bohumila Suchanová, Miroslav Kuchař and Lenka Skálová
    The Phase I Biotransformation of the Potential Antileukotrienic Drug Quinlukast in Rat Microsomes and Hepatocytes
    2004, Vol. 69, Issue 3, pp. 689–702 [Abstract]
  • Jiří Svoboda*, Michal Štádler, Antonín Jandera, Vladimíra Panajotová and Miroslav Kuchař
    Synthesis and Biological Evaluation of New Antiinflammatory 1-Benzothiophene-2-carboxanilides
    2000, Vol. 65, Issue 7, pp. 1082–1092 [Abstract]
  • Miroslav Kuchař, Marie Poppová, Antonín Jandera, Vladimíra Panajotovová, Hana Zůnová, Miloš Buděšínský, Hana Tomková, Alexandr Jegorov and Jan Taimr
    Chiral Forms of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid (Flobufen) and Its Metabolite.Synthesis and Basic Biological Properties
    1997, Vol. 62, Issue 3, pp. 498–509 [Abstract]
  • Miroslav Kuchař, Václav Vosátka, Marie Poppová, Eva Knězová, Vladimíra Panajotovová, Hana Tomková and Jan Taimr
    Some Analogs of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid: Synthesis and Antiinflammatory Activity
    1995, Vol. 60, Issue 6, pp. 1026–1033 [Abstract]
  • Miroslav Kuchař, Marie Poppová, Hana Zůnová, Eva Knězová, Václav Vosátka and Marek Příhoda
    4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid and Its Derivatives
    1994, Vol. 59, Issue 12, pp. 2705–2713 [Abstract]
  • Vojtěch Kmoníček, Martin Valchář and Zdeněk Polívka
    Some 4-Substituted 1-(3-Pyridylmethyl)piperazines with Antihistamine Activity
    1994, Vol. 59, Issue 10, pp. 2343–2350 [Abstract]
  • Karel Šindelář, Vojtěch Kmoníček, Marta Hrubantová and Zdeněk Polívka
    Substituted N,N-Dimethyl-3-(phenylthio)- and -4-(phenylthio)benzylamines
    1992, Vol. 57, Issue 1, pp. 194–203 [Abstract]
  • Vojtěch Kmoníček, Josef Pomykáček, Jiří Holoubek, Emil Svátek, Martin Valchář, Jiřina Metyšová and Zdeněk Polívka
    Potential antidepressants: 2-(fluoro-, chloro-, bromo- and cyanophenylthio)benzylamines as inhibitors of 5-hydroxytryptamine and noradrenaline re-uptake in brain
    1991, Vol. 56, Issue 11, pp. 2468–2481 [Abstract]
  • Ludmila Fišnerová, Bohumila Brunová, Zuzana Kocfeldová, Jana Tíkalová, Eva Maturová and Jaroslava Grimová
    Synthesis and analgetic efficiency of some oxy and oxo derivatives of 4(3H)-quinazolinone
    1991, Vol. 56, Issue 11, pp. 2373–2381 [Abstract]
  • Bohdan Schneider, Václav Rejholec and Miroslav Kuchař
    Three-dimensional structures of substituted diphenyl sulfides
    1990, Vol. 55, Issue 11, pp. 2590–2601 [Abstract]
  • Vojtěch Kmoníček, Emil Svátek, Jiří Holubek, Miroslav Ryska, Martin Valchář and Miroslav Protiva
    Synthesis of 1-acyl- and 1-(thioacyl)-4-benzylpiperazines as potential antidepressants
    1990, Vol. 55, Issue 7, pp. 1817–1827 [Abstract]
  • Vojtěch Kmoníček, Zdeněk Vejdělek and Miroslav Protiva
    Synthesis of a series of 5-methyl-1H-imidazole-4-ylmethyl sulfides
    1990, Vol. 55, Issue 6, pp. 1602–1612 [Abstract]
  • Miloš Beran, Antonín Černý, Miroslav Kuchař, Hana Adamírová, Jiří Holubek, Jan Taimr, Jaroslav Vachek, Maria Frühaufová, Karel Řežábek, Martin Valchář and Ivan Krejčí
    9,10-Dihydroergopeptines modified in position 6
    1990, Vol. 55, Issue 3, pp. 819–832 [Abstract]
  • Miroslav Kuchař, Jaroslava Grimová, Václav Rejholec, Hana Tomková, Magda Jelínková and Jiří Holubek
    Use of QSAR in design of antiinflammatory fluorinated arylalkanoic acids
    1990, Vol. 55, Issue 1, pp. 296–306 [Abstract]
  • Jiří Jílek, Karel Šindelář, Josef Pomykáček, Vojtěch Kmoníček, Zdeněk Šedivý, Marta Hrubantová, Jiří Holubek, Emil Svátek, Miroslav Ryska, Ivan Koruna, Martin Valchář, Antonín Dlabač, Jiřina Metyšová, Nataša Dlohožková and Miroslav Protiva
    Potential antidepressants: 2-(Methoxy- and hydroxyphenylthio)benzylamines as selective inhibitors of 5-hydroxytryptamine re-uptake in the brain
    1989, Vol. 54, Issue 12, pp. 3294–3338 [Abstract]
  • Jiří Jílek, Jiří Urban, Vojtěch Kmoníček, Josef Pomykáček, Jiří Holubek, Emil Svátek, Oluše Matoušová, Jan Metyš, Martin Valchář, Stanislav Wildt and Miroslav Protiva
    Potential anticonvulsants: 3-Chlorobenzophenone derivatives
    1989, Vol. 54, Issue 8, pp. 2248–2260 [Abstract]
  • Vojtěch Kmoníček, Zdeněk Vejdělek, Jiří Holubek, Martin Valchář and Miroslav Protiva
    Potential antidepressants: 1-(4-Aminoalkoxy)phenyl)-2-propylamines
    1989, Vol. 54, Issue 6, pp. 1721–1733 [Abstract]
  • Miroslav Kuchař, Eva Maturová, Bohumila Brunová, Jaroslava Grimová, Hana Tomková and Jiří Holubek
    Quantitative relations between structure and antiinflammatory activity of aryloxoalkanoic acids
    1988, Vol. 53, Issue 8, pp. 1862–1872 [Abstract]
  • Vojtěch Kmoníček, Jiří Holubek, Emil Svátek, Jiřina Metyšová and Miroslav Protiva
    2-(tert.amino)-11-(4-methylpiperazino)dibenzo[b,f]thiepins and their 10,11-dihydro derivatives; Synthesis and neuroleptic activity
    1987, Vol. 52, Issue 3, pp. 793–803 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Jaroslava Grimová, Stanislav Vaněček and Jiří Holubek
    Synthesis of cyclohexylaliphatic acids and their pharmacological properties
    1986, Vol. 51, Issue 12, pp. 2896–2908 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Jaroslava Grimová, Václav Rejholec and Václav Čepelák
    On the quantitative relations between structure and antiaggregation activity of ω-aryl-ω-oxoalkanoic acids
    1986, Vol. 51, Issue 11, pp. 2617–2625 [Abstract]
  • Vojtěch Kmoníček, Emil Svátek, Jiří Holubek and Miroslav Protiva
    Synthesis of potential neuroleptics and tranquillizers: 2-(tert.Amino)-9-(3-dimethylaminopropylidene)thioxanthenes
    1986, Vol. 51, Issue 4, pp. 937–947 [Abstract]
  • Václav Bártl, Vojtěch Kmoníček, Zdeněk Šedivý, Emil Svátek, Jiří Protiva and Miroslav Protiva
    Thioxanthene derivatives of pharmacological interest: 1,2,4-Trichloro and 2,4,5,6-tetrachloro derivatives of 9-(3-dimethylaminopropylidene)thioxanthene
    1984, Vol. 49, Issue 10, pp. 2295–2308 [Abstract]
  • Vojtěch Kmoníček, Václav Bártl and Miroslav Protiva
    Thioxanthene derivatives with neurotropic activity; synthesis of 9-(3-dimethylaminopropylidene)-2-(methylthiomethyl)thioxanthene and of some related compounds
    1984, Vol. 49, Issue 7, pp. 1722–1730 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Václav Rejholc, Magda Jelínková, Jiří Holubek and Oldřich Němeček
    Quantitative relations between structure and activation of fibrinolysis in selected series of arylaliphatic acids
    1984, Vol. 49, Issue 1, pp. 122–136 [Abstract]
  • Miroslav Kuchař, Václav Rejholec, Zdeněk Roubal and Oluše Matoušová
    The effects of lipophilicity on the inhibition of denaturation of serum albumin and on the activation of fibrinolysis observed with a series of benzyloxyarylaliphatic acids
    1983, Vol. 48, Issue 4, pp. 1077–1088 [Abstract]
  • Miroslav Kuchař, Václav Rejholec, Bohumila Brunová, Jaroslava Grimová, Oluše Matoušová, Oldřich Němeček and Hana Čepeláková
    Benzyloxyarylaliphatic acids: Synthesis and quantitative relations between structure and antiinflammatory activity
    1982, Vol. 47, Issue 9, pp. 2514–2524 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Václav Rejholec, Zdeněk Roubal and Oldřich Němeček
    The synthesis of arylpropionic acids and the quantitative relationship between the structure and the activation of fibrinolysis
    1981, Vol. 46, Issue 5, pp. 1173–1187 [Abstract]
  • Miroslav Kuchař, Bohumila Brunová, Zdeněk Roubal, Jiří Schlanger and Oldřich Němeček
    Synthesis of arylacetic acids and their effect on activation of fibrinolysis. Quantitative relations between structure and biological activity
    1980, Vol. 45, Issue 5, pp. 1401–1409 [Abstract]
  • Miroslav Kuchař, Václav Rejholec, Zdeněk Roubal and Oldřich Němeček
    Quantitative relationships between structure and fibrinolytic activity in the series of α-methyl-β-arylpropionic acids
    1979, Vol. 44, Issue 1, pp. 183–193 [Abstract]