Collect. Czech. Chem. Commun. 1989, 54, 784-795

Atriopeptins. II. Synthesis of N-terminal fragments

Mikhail V. Ovchinnikov, Zhanna D. Bespalova, Aleksandr S. Molokoedov, Inna V. Revenko, Nikolai F. Sepetov, Olga L. Isakova and Mikhail I. Titov

Cardiology Research Center of the U.S.S.R., Academy of Medical Sciences, 121552 Moscow, U.S.S.R.


Peptides, corresponding to the N-terminal sequence in atriopeptins, were synthesized by classical methods of peptide chemistry in solution. The obtained peptides were characterized by various physicochemical methods. The scheme and methods of the synthesis are discussed.