Collect. Czech. Chem. Commun. 1989, 54, 772-783

Atriopeptins. I. Synthesis of C-terminal fragments

Mikhail V. Ovchinnikov, Zhanna D. Bespalova, Aleksandr S. Molokoedov, Inna V. Revenko, Nikolai F. Sepetov, Olga L. Isakova and Mikhail I. Titov

Cardiology Research Center of the U.S.S.R., Academy of Medical Sciences, 121552 Moscow, U.S.S.R.


Peptides, corresponding to the C-terminal sequence in atriopeptins, have been synthesized using classical methods of peptide synthesis in solution and chracterized by various physicochemical methods. The synthetic strategy and methods are discussed.