Collect. Czech. Chem. Commun. 1989, 54, 796-802
https://doi.org/10.1135/cccc19890796

Atriopeptins. III. Synthesis and biological activity studies of α-r-ANF, AP-II, AP-III and des-Ser5-Ser6-AP-II

Mikhail V. Ovchinnikov, Zhanna D. Bespalova, Aleksandr S. Molokoedov, Mikhail I. Titov, Inna V. Revenko, Valentin A. Vinogradov, Nikolai V. Korobov and Sergei V. Zhukovskii

Cardiology Research Center of the U.S.S.R., Academy of Medical Sciences, 121552 Moscow, U.S.S.R.

This article is part of serial Atriopeptins.

Abstract

Starting from previously synthesized atriopeptin fragments, peptides α-r-ANF, AP-II, AP-III and des-Ser5-Ser6-AP-II were prepared using complex F. The acetamidomethyl protecting group on cysteine was removed simultaneously with the cyclization. Biological activity of atriopeptin was evaluated.