Collect. Czech. Chem. Commun. 1988, 53, 202-208

Proteoglycan-collagen interactions. Structure in the amorphous ground substance

John E. Scott

Department of Chemical Morphology, University of Manchester Manchester M13 9PL, England


Glycosaminoglycans occur in vivo outside the collagen fibrils. In this perifibrillar space specific interactions between proteoglycans and the collagen fibrils lead to the formation of an organized structure. Different tissues were examined by an electron histochemical method and it was concluded that the single proteoglycans have specific loci of association with the type I collagen fibril and are arrayed orthogonally in respect to the fibrils.