Collect. Czech. Chem. Commun. 1981, 46, 1976-1982

Syntheses of 17β-(2-maleimido)androstanes

Pavel Drašar and Miroslav Havel

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


Starting from pregnane derivatives, 17β-(2-maleimido)androstanes of 5α- and Δ5-series, with and without a 3β-acetoxy group, were prepared via methyl 3-androstanyl-3-cyano acrylates. The maleimidoandrostanes were synthesized as models of cardiotonic steroids.