Collect. Czech. Chem. Commun. 1981, 46, 1983-1989

Use of phenylacetyl group for protection of the lysine Nε-amino group in synthesis of peptides

František Brtník, Tomislav Barth and Karel Jošt

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


Nε-Phenylacetyllysine was used in the synthesis of deamino-lysine-vasopressin. The phenylacetyl protecting group is stable under conditions of peptide synthesis and can be removed by action of penicillin amidohydrolase (E.C. without damaging the built peptide chain.