Collect. Czech. Chem. Commun. 2011, 76, 27-37
Published online 2010-12-06 09:27:41

An efficient synthesis of 2-arylbenzothiazoles using silica sulfuric acid, oxalic acid and aluminum chloride hydrate as heterogeneous and homogeneous catalyst systems

Behrooz Maleki

Department of Chemistry, Sabzevar Tarbiat Moallem University, 397 Sabzevar, Iran


A convenient method for the synthesis of 2-arylbenzothiazoles from condensation of aromatic/heteroaromatic aldehydes with 2-aminothiophenol has been developed using inexpensive, green and reusable solid acids – silica sulfuric acid (SSA), oxalic acid or AlCl3·6H2O as efficient catalysts. The reactions occurred under mild conditions to afford the corresponding 2-arylbenzothiazoles in good to excellent yields.

Keywords: Acidity; Aldehydes; Antibiotics; Antibacterial activity; Antiaromaticity; Antifungal activity; 2-Arylbenzothiazoles; Silica sulfuric acid; Oxalic acid; AlCl3·6H2O; 2-Aminothiophenol.

References: 63 live references.