Collect. Czech. Chem. Commun. 2009, 74, 1361-1373
Published online 2009-09-16 22:07:00

QSAR analysis of 2-oxo-1,2,3,4-tetrahydropyrimidine analogues of antibacterials

Ramesh L. Sawanta,* and Manish S. Bhatiab

a Department of Pharmaceutical Chemistry, Pd. Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad Ghat, Post-MIDC, Ahmednagar-414111, Maharashtra, India
b Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, Maharashtra, India


QSAR analysis of two sets of analogues of 2-oxo-1,2,3,4-tetrahydropyrimidine was performed to investigate the relationship between their physicochemical parameters and antibacterial activity. Predictive and statistically significant models were generated. On the basis of these models new compounds were synthesized, structurally characterized and evaluated for their antibacterial potential. The potential of newly synthesized compounds was higher than the training set of compounds, in close agreement with QSAR prediction.

Keywords: QSAR; 2-Oxo-1,2,3,4-tetrahydropyrimidine; Antibacterial activity; Electronic features; Steric features.

References: 22 live references.