Collect. Czech. Chem. Commun. 2007, 72, 1005-1013

Exploring the Substrate Scope of the Ru(II)-Catalyzed Kharasch Reaction

Eskender Mume, Ian J. Munslow, Klas Källström and Pher G. Andersson*

Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, S-751 23 Uppsala, Sweden


The Kharasch reaction, or atom-transfer addition of polyhalogenated alkanes to alkenes is known to be catalyzed by a number of Ru(II) complexes. The easily prepared [RuCl2(PPh3)3] was used to investigate the reaction scope. A number of halogenated alkanes were added to a range of alkenes with good to excellent regioselectivities.

Keywords: Atom transfer; Ruthenium; Alkenes; Catalysis; Additions; Polyhalogenated alkanes.

References: 43 live references.