Collect. Czech. Chem. Commun. 2007, 72, 1646-1658

Boron Units as Pharmacophores - New Applications and Opportunities of Boron Cluster Chemistry

Zbigniew J. Lesnikowski

Laboratory of Molecular Virology and Biological Chemistry, Center of Medical Biology, Polish Academy of Sciences, Lodz 93-232, Poland


Carboranes (dicarba-closo-dodecaboranes) are a class of carbon-containing polyhedral boron-cluster compounds showing remarkable hydrophobic character, chemical and thermal stability, and resistance to catabolism in biological environment. These features allow application of boron clusters as new hydrophobic core structure in biologically active molecules that interact hydrophobically with proteins, thus facilitating new drug design. A review with 45 references.

Keywords: Carboranes; Metallacarboranes; Drugs; Pharmacophores; Medicinal chemistry; Hydrophobicity; Nucleosides; Cholesterol mimics.

References: 45 live references.