Collect. Czech. Chem. Commun. 2004, 69, 897-904

Facile Synthesis of Aryl-Substituted 1,2,5,6-Tetrahydropyrimidines and Their Stereochemical Investigation

Valentin A. Chebanov*, Elena A. Muravyova, Yulia V. Sadchikova, Sergey M. Desenko, Vitaly N. Chernenko, Kiril M. Kobzar and Vladimir I. Musatov

Department of Photoactive Heterocyclic Compounds, Scientific and Technological Corporation "Institute for Single Crystals", National Academy of Science of Ukraine, Lenin Ave. 60, 61001 Kharkiv, Ukraine


The present work is devoted to the investigation of 2,4,6-triaryl-1,2,5,6-tetrahydropyrimidine derivatives. A new facile approach to their synthesis based on the reaction of α,β-unsaturated ketones, carbonyl compounds and ammonia was developed. Some stereochemical features of the compounds obtained were fixed on the base of NMR data (including COSY and NOESY experiments).

Keywords: Nitrogen heterocycles; 1,2,5,6-Tetrahydropyrimidines; Multicomponent reactions; Synthetic methods; Structure elucidation; NMR spectroscopy; Chalcones; Pyrimidines; Heterocyclizations.

References: 7 live references.