Collect. Czech. Chem. Commun. 2001, 66, 1841-1848

The 1H and 13C NMR Chemical Shift Assignments for Thirteen Bufadienolides Isolated from the Traditional Chinese Drug Ch'an Su

Yoshiaki Kamanoa, Toshihiko Nogawaa, Ayano Yamashitaa and George R. Pettitb,*

a Faculty of Science, Kanagawa University, 2946, Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan
b Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-2404, U.S.A.


The 1H and 13C NMR spectra of thirteen natural bufadienolides, which were isolated from the Chinese drug Ch'an Su, were assigned using a combination of 2D NMR spectra that included 1H-1H COSY, NOESY, HMQC, and HMBC techniques.

Keywords: Ch'an Su; Bufadienolides; Steroids; NMR spectroscopy, 1H and 13C; Assignment of signals; Cardiotonic; Antitumor activity.

References: 36 live references.