Collect. Czech. Chem. Commun. 2001, 66, 1831-1840

Synthesis of Some Steroidal Oxazolines

János Wölfling, Erzsébet Mernyák, Melinda Sebők and Gyula Schneider*

Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, Hungary


Steroidal oxazolines 4a-4d and 5a-5f were synthesized. The acid-catalyzed reactions of 21-azido-20-hydroxy- and 21-hydroxy-20-azidosteroids with substituted aromatic aldehydes led to the formation of androst-5-en-3β-ols substituted in position 17β with oxazoline residues.

Keywords: Steroids; Vicinal-azidoalcohols; Oxazolines; Schmidt reaction.

References: 13 live references.