Collect. Czech. Chem. Commun. 1999, 64, 417-434

Synthesis and Antimicrobial Activity of New 4-(Benzylsulfanyl)pyridine Derivatives

Věra Klimešováa,*, Martin Svobodaa, Karel Waissera, Milan Poura and Jarmila Kaustováb

a Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic
b National Reference Laboratory for Mycobacterium Kansasii, Regional Institute of Hygiene, 728 92 Ostrava, Czech Republic


A series of 4-(benzylsulfanyl)pyridine-2-carbonitriles 2 and 4-(benzylsulfanyl)pyridine-2- carbothioamides 3 was synthesized and their antimycobacterial and antifungal activities were tested. The prepared compounds exhibit significant activity both against M. tuberculosis and nontuberculous mycobacteria. The most active compounds show the MICs of 4 μmol/l. The antifungal activities of 2 are very weak, compounds 3 are inactive against all the tested fungi.

Keywords: Pyridinecarbonitriles; Pyridinecarbothioamides; Tuberculostatics; Antimycobacterial activity; Antifungal activity; QSAR.