Collect. Czech. Chem. Commun. 1997, 62, 1325-1341

Prostanoids: Synthesis of Enantiomers of 15-Deoxy-16-hydroxy-16-methylprostaglandin E1

Miroslav Terinek, Václav Kozmík and Jaroslav Paleček

Institute of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6,Czech Republic


Four optically pure isomers of methyl 11,16-dihydroxy-16-methyl-9-oxoprost-13-enoate (1a-1d) were synthesized using an approach reverse to the classical Corey procedure, the key intermediates being the easily accessible (-)- and (+)-enantiomers of the Corey lactone, 2a and 2b.

Keywords: Prostaglandins; Enantiomeric resolution.