Collect. Czech. Chem. Commun. 1997, 62, 948-956

Synthesis of Some "Abbreviated" NAD+ Analogues

Dana Hocková and Antonín Holý

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic


Four new "abbreviated" NAD+ analogues with hydroxymethyl or carboxyl function as a substituent of an aliphatic chain linking the adenine and nicotinamide moieties were prepared using the Zincke reaction as the key step. As intermediates several new acyclic nucleoside analogues containing hydroxy, carboxyl, azido and amino group were prepared.

Keywords: Nicotinamide adenine dinucleotide; Zincke reaction; Acyclic nucleoside analogues; Pyridinium salts.