Collect. Czech. Chem. Commun. 1997, 62, 665-671

An Effective Synthesis of 1,3-Oxathiolanes

Ludvík Streinz, Bohumír Koutek and David Šaman

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic,166 10 Prague 6, Czech Republic


2-Alkyl- or 2,2-dialkyl-1,3-oxathiolanes can be effectively prepared from aldehydes or ketones and 2-mercaptoethanol, with triisopropylsilyl triflate as a catalyst. The reaction is over within minutes and, despite the fact that water is nor removed during the reaction, the yields of products are high.

Keywords: Ketone; Aldehyde; Protection; 1,3-Oxathiolane.