Collect. Czech. Chem. Commun. 1997, 62, 1623-1630

(-)-Armepavine: Gradient-Enhanced 2D NMR Study and X-Ray Crystal Structure Determination

Radek Mareka, Jaromír Mareka, Jiří Dostálb and Jiří Slavíkb

a Laboratory of Biomolecular Structure and Dynamics, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic
b Department of Biochemistry, Faculty of Medicine, Masaryk University, 662 43 Brno, Czech Republic


(-)-Armepavine, a benzylisoquinoline alkaloid isolated from Papaver caucasicum, was examined by gradient-enhanced 2D NMR spectroscopy and X-ray diffraction analysis. Unambiguous 1H, 13C, and 15N NMR assignment of the title alkaloid is reported.

Keywords: (-)-Armepavine; Isoquinoline alkaloids; Papaver caucasicum; Gradient-enhanced 2D NMR spectroscopy; X-Ray crystallography.