Collect. Czech. Chem. Commun. 1996, 61, 1244-1247

Antioxidant Building Blocks I. The Unexpected C-Acetylation of 2,6-Di-tert-butylphenol with Isopropenyl Acetate

Tibor Gizur, György G. Ferenczy, Éva Ágai-Csongor and György Domány

Chemical Works of Gedeon Richter Ltd., Budapest 10, P.O. Box 27, H-1475 Hungary


While the reaction of some 2-substituted and 2,6-disubstituted phenols with isopropenyl acetate resulted in the corresponding phenol acetates, in the reaction of 2,6-di-tert-butylphenol, a useful starting material of antioxidant building blocks, under the same conditions 4-acetyl-2,6-di- tert-butylphenol was the only product.

Keywords: 2,6-Di-tert-butylphenol acylation; Isopropenyl acetate reaction.