Collect. Czech. Chem. Commun. 1996, 61, 1815-1822

Alkaloids of Meconopsis cambrica (L.) VIG. and M. robusta HOOK. f. et THOMS.

Jiří Slavík and Leonora Slavíková

Biochemical Institute of Medical Faculty, Masaryk University, 662 43 Brno, Czech Republic


Additional alkaloids (+)-roemerine (3b), (+)-corytuberine (3d), (-)-N-methylmecambridinium and alkaloid MC 2 (the last two as iodides) were isolated as minor alkaloidal components from Meconopsis cambrica (L.) VIG. (Papaveraceae) besides of the dominant known alkaloids (-)-mecambrine (1), (-)-mecambridine (2), (-)-flavinantine (4) and (+)-magnoflorine (5), and a small amount of (+)-mecambroline (3a). Minute quantities of protopine, allocryptopine, roemeroline, papaverrubine D and C, berberine, coptisine, corysamine and palmatine were identified by thin layer chromatography (TLC). From M. robusta HOOK. f. et THOMS., protopine, (-)-amurensinine (6) and two incompletely characterized alkaloids MRO 1 and MRO 2 were isolated, and allocryptopine, cryptopine, rhoeadine, 6-methoxy-2-methyl-1,2,3,4-tetrahydro-β-carboline, alkaloid MR 1, coptisine, corysamine, magnoflorine, corytuberine and N-methylamurensininium salt were detected on TLC.

Keywords: Meconopsis cambrica; Meconopsis robusta; Papaveraceae; Minor alkaloids.