Collect. Czech. Chem. Commun. 1996, 61, 1642-1646

Synthesis of New [1,3]Diazaheterocyclo[2',1':2,3][1,3,5]thiadiazino[4,5-f]purine Ring Systems

Dušan Heseka, Alfonz Rybárb, Juraj Alföldib, Juraj Bellaa and Vladimír Pätoprstýb

a Drug Research Institute, 900 01 Modra, Slovak Republic
b Institute of Chemistry, Slovak Academy of Sciences, Dúbravska cesta 9, 842 38 Bratislava, Slovak Republic


A simple method for preparation of the title ring systems 3a-3d starting from 7-chloromethyl-8-chloro-1,3-dimethyl-7H-purine-2,6(1H,3H)-dione (1) and cyclic isothioureas 2 is described. First, alkylation of the mercapto group of compound 2 took place to give 7-isothiuronium derivative 5, which in turn cyclized to the final product 3 in alkaline medium.

Keywords: Annelation reactions; [1,3,5]Thiadiazino[4,5-f]purinediones.