Collect. Czech. Chem. Commun. 1996, 61, 1509-1519

New Synthesis of Important Prostanoid Intermediate

Jiří Svobodaa, Václav Kozmíka, Ivan Veselýb and Jaroslav Palečeka

a Institute of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic
b Spolana, Department for Development, 277 11 Neratovice, Czech Republic


New synthesis of intermediates for the preparation of prostaglandin analogs of the E1 series is described. The simple synthesis starts from commercially accessible Corey acetate 1 and makes use of simultaneous protection of the two hydroxy groups in the form of cyclic acetal. No expensive protecting reagents are required and the synthetic sequence leading to the end product is shorter.

Keywords: Prostaglandins; Misoprostol; Acetals.