Collect. Czech. Chem. Commun.
1995, 60, 1186-1190
https://doi.org/10.1135/cccc19951186
Synthesis of trans β-Lactams of Estrane Series
Abdul U. Siddiqui, Yelluru Satyanarayana and Abdul H. Siddiqui
Department of Chemistry, Nizam College, Osmania University, Hyderabad-500001, India
Abstract
17,17-Ethylenedioxy-1,3,5(10)-estratrien-3β-ol (I) was converted into ethyl ester II by reaction with ethyl chloroacetate in the presence of potassium. The ethyl ester II on reaction with hydrazine gave hydrazide III, which on condensation with aromatic aldehydes gave Schiff bases IVa-IVd. The reaction of Schiff bases IVa-IVd with chloroacetyl chloride in the presence of triethylamine afforded β-lactams Va-Vd.
