Collect. Czech. Chem. Commun. 1995, 60, 612-618

Synthesis of Pyrazole Analogs from Argentatin B

Roberto Martínez, Elda Limón, María del R. Arellano, Mariano Martínez and Marco Brito

Instituto de Química, Universidad Nacional Autonoma de Mexico. Circuito Exterior, Ciudad Universitaria, Coyoacan 04510, Mexico, D. F., Mexico


The pyrazole derivatives 3'-(2-R-phenyl)[3,2-c]pyrazole-16,24-epoxy-25-hydroxy-9 ,19-cyclostane Va - Vf have been prepared in a three step reaction from argentatin B. The structure of all the compounds synthesized was corroborated by 1H and 13C NMR, IR and mass spectroscopy.