Collect. Czech. Chem. Commun. 1994, 59, 1451-1457

Synthesis of Bicyclic Pyridine Tripeptides

Abd El-Hamid Attia, Mohamed H. Abo-Ghalia and Osama I. Abd El-Salam

National Research Centre, Dokki, Cairo, Egypt


Dinicotinic acid reacted with L-phenylalanine affording N-dinicotinoyl-bis-L-phenylalanine (VII). The same product was also obtained by mild alkaline hydrolysis of the corresponding ester VI. Coupling of VII with L-ornithine or L-ornithine methyl ester gave rise to the formation of the desired chiral bicyclic tripeptides IIIa and IIIb as enniatin analogues.